{"id":"W2148031163","doi":"10.4049/jimmunol.1004125","title":"Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Centers for Disease Control and Prevention","keywords":"Cytotoxic T cell; Diphtheria toxin; CTL*; CD8; Cancer research; CD11c; Biology; Immunotherapy; Tumor microenvironment; Dendritic cell; Immunology; Cell biology; Chemistry; Immune system; Tumor cells; Toxin; In vitro; Microbiology; Phenotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008999494,0.0004047764,0.0002418313,0.0001722493,0.00007747203,0.0002666581,0.0001119863,0.0001641121,0.0008639778],"category_scores_gemma":[0.000093222,0.00009672022,0.0001409884,0.00007596986,0.000161837,0.0001171013,0.000142114,0.0006987696,0.0003479898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115126,"about_ca_system_score_gemma":0.0001371783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001253387,"about_ca_topic_score_gemma":0.0002467334,"domain_scores_codex":[0.9998819,0.00002219897,0.000008162388,0.00001669078,0.0000289061,0.00004219399],"domain_scores_gemma":[0.9999057,0.00001848666,0.0000246408,0.00001884398,0.000007036955,0.00002526875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009645562,0.00007455489,0.0001727224,0.00002479733,0.000001809966,0.00002559139,0.000007862121,0.00009679344,0.9973353,0.00009548046,0.00004483584,0.002023848],"study_design_scores_gemma":[0.00002944168,0.0004048061,0.0009766985,0.000003760575,0.000008903678,0.0002128221,0.000009400949,0.0007052218,0.9957857,0.00005708763,0.001804821,0.000001376965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934122,0.001364113,0.002491897,0.0001299876,0.00004077063,0.0000251024,0.0001205617,0.0001393091,0.002276071],"genre_scores_gemma":[0.995599,0.0006871354,0.001802798,0.00004347624,0.00002477903,0.00001968517,0.0001534198,0.00001894882,0.001650844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008639778,"threshold_uncertainty_score":0.002890289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441365399080456,"score_gpt":0.2279392984915034,"score_spread":0.2135256445006988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}