{"id":"W2148034261","doi":"10.1093/hmg/ddg219","title":"Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia","year":2003,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"FANCA; Biology; Fanconi anemia; Genetics; Meiosis; Germ cell; Molecular biology; Gene; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046963,0.0005711358,0.000200845,0.0004381767,0.0001727011,0.0001637193,0.0002450873,0.0003903066,0.001693847],"category_scores_gemma":[0.0001104277,0.0002346145,0.0002355491,0.0001715114,0.0003462158,0.0000926662,0.000227083,0.0005018864,0.0005766664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205349,"about_ca_system_score_gemma":0.0001700904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008166552,"about_ca_topic_score_gemma":0.001271822,"domain_scores_codex":[0.9998522,0.00002097157,0.00001691972,0.00004471487,0.00004216837,0.00002303815],"domain_scores_gemma":[0.9997863,0.00003902425,0.00009412009,0.00001818389,0.000009263894,0.00005300707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000301875,0.00001433182,0.0001454667,0.00001696241,0.000003835444,0.0001182001,0.000008180549,0.00005218789,0.9987882,0.00005541773,0.0000455421,0.0007214423],"study_design_scores_gemma":[0.00003597198,0.0002914515,0.01591873,0.00001181075,0.0000320688,0.002475483,0.0000274727,0.001011799,0.9762239,0.00007885911,0.003881256,0.00001109422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941891,0.0009994679,0.002353923,0.00007699073,0.00002917143,0.00004562994,0.0008946562,0.0002344421,0.001176622],"genre_scores_gemma":[0.9868367,0.001419949,0.002833016,0.00007542534,0.00002369749,0.00006057604,0.001581982,0.00007003633,0.007098589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001693847,"threshold_uncertainty_score":0.005666494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008323677484504147,"score_gpt":0.2221840839133263,"score_spread":0.2138604064288221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}