{"id":"W2148047944","doi":"10.1158/1535-7163.mct-14-0521","title":"Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Transactivation; Androgen receptor; CYP17A1; Enzalutamide; LNCaP; Prostate cancer; In vivo; Chemistry; Reporter gene; Luciferase; Androgen deprivation therapy; Cancer research; Internal medicine; Pharmacology; Biology; Cancer; Transfection; Medicine; Gene expression; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144003,0.0003789894,0.0004612859,0.0004359261,0.000149615,0.0003107716,0.0002473864,0.0002066162,0.001369216],"category_scores_gemma":[0.0001057813,0.0001880793,0.0003063003,0.0003910806,0.0001282261,0.0001910691,0.0001025545,0.0005881047,0.0002662694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036329,"about_ca_system_score_gemma":0.0003866077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001998816,"about_ca_topic_score_gemma":0.005710814,"domain_scores_codex":[0.9998984,0.00002061515,0.00000796868,0.00001446329,0.00003408243,0.00002443649],"domain_scores_gemma":[0.9999197,0.000009048311,0.00002424992,0.000008375106,0.00001230583,0.00002647179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001770825,0.0007515628,0.0006084104,0.0002060168,0.00007010659,0.00009750031,0.00002812366,0.0009630068,0.9784366,0.0001539357,0.0004194854,0.01649435],"study_design_scores_gemma":[0.0005894465,0.01783688,0.01074414,0.00002549651,0.0001923096,0.0009264102,0.00006583095,0.002781771,0.9550583,0.00008227315,0.01167072,0.00002648097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878908,0.006377654,0.001872927,0.0001247453,0.00005980967,0.0001022691,0.001052678,0.0002177223,0.002301243],"genre_scores_gemma":[0.9878678,0.00470024,0.001613637,0.00006219593,0.00001812895,0.00006356402,0.001748105,0.00002594703,0.003900314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001998816,"threshold_uncertainty_score":0.004580438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07939099133391246,"score_gpt":0.389856849388072,"score_spread":0.3104658580541595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}