{"id":"W2148103638","doi":"10.1593/neo.07142","title":"Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision","year":2007,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene silencing; Biology; Cell biology; Protein kinase B; Cancer research; Downregulation and upregulation; Actin cytoskeleton; Programmed cell death; Small interfering RNA; Signal transduction; Cell; Cell culture; Transfection; Cytoskeleton; Biochemistry; Gene; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005245231,0.0002577011,0.000197827,0.0001117411,0.000109575,0.0001705814,0.0001262821,0.000227705,0.0006251554],"category_scores_gemma":[0.00004110148,0.00008832398,0.0002231515,0.00008821506,0.0001833858,0.0001577657,0.00009790054,0.0004056842,0.0002245041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489893,"about_ca_system_score_gemma":0.0001262908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004165461,"about_ca_topic_score_gemma":0.0006206169,"domain_scores_codex":[0.9999471,0.000005825159,0.000003726001,0.00001131046,0.00001625927,0.00001590442],"domain_scores_gemma":[0.9999741,0.000003402485,0.000008562317,0.000004128133,0.000003039155,0.000006715092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005299671,0.00001175021,0.0001165319,0.00001200837,0.000001595084,0.0000561154,0.000006334259,0.00003430305,0.9990764,0.00009973531,0.00002120399,0.0005110011],"study_design_scores_gemma":[0.00001039842,0.0001299348,0.002690307,0.000001645257,0.000004958109,0.0001676161,0.00001107664,0.0005655176,0.9953929,0.00007286826,0.0009506704,0.000002094326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922124,0.0009535612,0.004232026,0.0002073855,0.00003333834,0.00002933427,0.0003929612,0.0001558286,0.001783074],"genre_scores_gemma":[0.9957992,0.0004489876,0.002222792,0.000076055,0.000005657781,0.00002533188,0.0003055214,0.000009963866,0.001106534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006251554,"threshold_uncertainty_score":0.002091408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554112107996576,"score_gpt":0.2461798923696411,"score_spread":0.2306387712896754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}