{"id":"W2148103638","doi":"10.1593/neo.07142","title":"Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision","year":2007,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene silencing; Biology; Cell biology; Protein kinase B; Cancer research; Downregulation and upregulation; Actin cytoskeleton; Programmed cell death; Small interfering RNA; Signal transduction; Cell; Cell culture; Transfection; Cytoskeleton; Biochemistry; Gene; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005600808,0.0001851143,0.0001481771,0.0001487994,0.00009830244,0.00003243878,0.0001213762,0.0003175273,0.00002003354],"category_scores_gemma":[0.00005031241,0.0001637746,0.0001043791,0.0003141682,0.00001818968,0.00002061323,0.00002020865,0.0001746476,0.000005306814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000786438,"about_ca_system_score_gemma":0.00008120963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002190049,"about_ca_topic_score_gemma":0.001332331,"domain_scores_codex":[0.9987202,0.00003023771,0.0003667716,0.0003962246,0.0001771429,0.000309409],"domain_scores_gemma":[0.9993927,0.0001123861,0.0001268687,0.0002388677,0.00006298314,0.00006622048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005390087,0.00007248155,0.002968244,0.00002003294,0.00001397111,0.000001559097,0.0002111602,0.0007162061,0.9778393,0.00001659551,0.0001256421,0.01262471],"study_design_scores_gemma":[0.003080334,0.0009814828,0.01671374,0.00005824819,0.00003991347,0.000002592884,0.000232638,0.000399378,0.970656,0.0002534643,0.007355473,0.0002267145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8071231,0.0001404177,0.1915796,0.00005025238,0.0004287008,0.0005800189,0.000003072901,0.00001270207,0.00008217043],"genre_scores_gemma":[0.9980852,0.00005269029,0.0009900467,0.00005710926,0.0003111912,0.00003551791,0.0002498718,0.00002911734,0.0001892713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1909621,"threshold_uncertainty_score":0.6678533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554112107996576,"score_gpt":0.2461798923696411,"score_spread":0.2306387712896754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}