{"id":"W2148138182","doi":"10.1093/toxsci/kfu095","title":"Target Organ Specific Activity of Drosophila MRP (ABCC1) Moderates Developmental Toxicity of Methylmercury","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"Argonne National Laboratory; Basic Energy Sciences; National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; Office of Science; U.S. Department of Energy","keywords":"Methylmercury; Gene knockdown; Drosophila melanogaster; Caenorhabditis elegans; Toxicity; Biology; Mutant; Developmental toxicity; Danio; Genetics; Transporter; Cell biology; Toxicology; Gene; Biochemistry; Zebrafish; Internal medicine; Bioaccumulation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008992442,0.0001509747,0.0004955311,0.00007890622,0.0001444965,0.00001056758,0.0002415471,0.0001297749,0.0009137959],"category_scores_gemma":[0.0001283691,0.00009365442,0.0001040024,0.000461303,0.0008761363,0.00009885868,0.00004549552,0.0001358918,0.000008369494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003594153,"about_ca_system_score_gemma":0.0001320142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007337428,"about_ca_topic_score_gemma":0.000008270396,"domain_scores_codex":[0.9984455,0.00007502198,0.0003159205,0.0003509347,0.000514964,0.0002976733],"domain_scores_gemma":[0.9993688,0.0001395743,0.0001381688,0.000116818,0.0000658334,0.0001707773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270378,0.0004874689,0.006967733,0.00003487317,0.00001327518,0.000005227209,0.0001346868,0.00003771473,0.9841436,0.005067949,0.00004369608,0.002936793],"study_design_scores_gemma":[0.0003735985,0.0007905712,0.06779661,0.00003719381,0.00001453691,0.000006423805,0.0001421076,0.0003031244,0.9247459,0.005066585,0.0005958407,0.0001275304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862432,0.00009474588,0.002091617,0.0005779162,0.0001227539,0.0002052932,0.000007753436,0.00003759872,0.01061915],"genre_scores_gemma":[0.9807211,0.00004137398,0.01889464,0.0001359447,0.00004895259,0.000005618771,0.000002642242,0.000005074034,0.0001446321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06082888,"threshold_uncertainty_score":0.9999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03988205952817992,"score_gpt":0.2780683071402898,"score_spread":0.2381862476121099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}