{"id":"W2148138182","doi":"10.1093/toxsci/kfu095","title":"Target Organ Specific Activity of Drosophila MRP (ABCC1) Moderates Developmental Toxicity of Methylmercury","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"Argonne National Laboratory; Basic Energy Sciences; National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; Office of Science; U.S. Department of Energy","keywords":"Methylmercury; Gene knockdown; Drosophila melanogaster; Caenorhabditis elegans; Toxicity; Biology; Mutant; Developmental toxicity; Danio; Genetics; Transporter; Cell biology; Toxicology; Gene; Biochemistry; Zebrafish; Internal medicine; Bioaccumulation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404786,0.000304002,0.0003254818,0.0002359513,0.0001891485,0.0003794394,0.0003036353,0.0003745643,0.001862638],"category_scores_gemma":[0.0001572975,0.000205231,0.0002683577,0.0001465027,0.0002111746,0.0002011389,0.0002183313,0.0007716178,0.0004210726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953954,"about_ca_system_score_gemma":0.0002891984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002071593,"about_ca_topic_score_gemma":0.00439542,"domain_scores_codex":[0.9998248,0.00002104446,0.00002004988,0.00004116344,0.0000451471,0.00004774677],"domain_scores_gemma":[0.9998314,0.00002517098,0.00004905492,0.00001410934,0.00002630829,0.00005383967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411084,0.00004106328,0.0003182524,0.00005241905,0.000009115671,0.00002729073,0.0000139309,0.00005335066,0.9981792,0.00005617686,0.0001299349,0.0009780737],"study_design_scores_gemma":[0.00004404847,0.0005990349,0.01364716,0.00001250418,0.00005890218,0.0001282885,0.00006907219,0.00164062,0.9785994,0.00004327847,0.005144463,0.00001310407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944714,0.001275651,0.001032447,0.000216639,0.00004098155,0.00004342688,0.001187752,0.0001301657,0.001601465],"genre_scores_gemma":[0.9894063,0.001057558,0.001589552,0.0001528333,0.00001079812,0.00008819973,0.001291698,0.00006370224,0.006339328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071593,"threshold_uncertainty_score":0.006231189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03988205952817992,"score_gpt":0.2780683071402898,"score_spread":0.2381862476121099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}