{"id":"W2148148974","doi":"10.1158/1535-7163.mct-14-0337","title":"Interactions of Multitargeted Kinase Inhibitors and Nucleoside Drugs: Achilles Heel of Combination Therapy?","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Pharmacology; Gemcitabine; Sunitinib; Pazopanib; Cytotoxicity; Axitinib; Nucleoside; Medicine; Nucleoside analogue; Erlotinib; Tyrosine kinase; Cancer research; Chemistry; Cancer; Biochemistry; Internal medicine; In vitro; Receptor; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820975,0.00009893857,0.0003040772,0.0001096539,0.00003994563,0.000003812343,0.00005204548,0.00006821515,0.00003793302],"category_scores_gemma":[0.00002638934,0.00008343739,0.00006028582,0.0001260183,0.0001938409,0.00002931421,0.00001917506,0.0001547847,8.772462e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003686379,"about_ca_system_score_gemma":0.0000641666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121321,"about_ca_topic_score_gemma":0.00001360419,"domain_scores_codex":[0.9992195,0.0001126506,0.0002344083,0.0001184541,0.0001898842,0.0001251138],"domain_scores_gemma":[0.999388,0.0001124114,0.00008917058,0.0001824764,0.0001719077,0.00005607724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003393315,0.0004774914,0.07550266,0.0001792458,0.0006369499,0.000003305664,0.002164019,0.00002062807,0.8117282,0.0007927192,0.00006653806,0.1080889],"study_design_scores_gemma":[0.008540665,0.001627751,0.1278515,0.0004362481,0.0005862238,0.00001289875,0.001032105,0.02957438,0.8135588,0.001035515,0.01545011,0.0002937555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935845,0.003229717,0.001029511,0.0007394311,0.00008182001,0.0002855429,0.000008217986,0.00001724673,0.001023973],"genre_scores_gemma":[0.9967495,0.00194865,0.0007124346,0.0004377338,0.00002316042,0.00002534005,0.000008850745,0.00001928829,0.00007502984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1077952,"threshold_uncertainty_score":0.3402478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02687685274115872,"score_gpt":0.3443844929246337,"score_spread":0.317507640183475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}