{"id":"W2148161442","doi":"10.1073/pnas.1200330109","title":"Identification of olivetolic acid cyclase from <i>Cannabis sativa</i> reveals a unique catalytic route to plant polyketides","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":294,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute; University of Saskatchewan","funders":"","keywords":"Polyketide; Cannabinoid; Cyclase; Polyketide synthase; Biology; Biochemistry; Biosynthesis; Enzyme; Stereochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009039132,0.00008984292,0.0001532112,0.0001320318,0.00007624444,0.00001094852,0.0006412099,0.00008643634,0.000004882223],"category_scores_gemma":[0.0007381685,0.00006419998,0.00009571733,0.0004179871,0.0002495401,0.00003535329,0.0001822293,0.00006012316,0.000001752897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001660149,"about_ca_system_score_gemma":0.00003514575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002979687,"about_ca_topic_score_gemma":4.193612e-7,"domain_scores_codex":[0.9986705,0.00001455858,0.0003808873,0.0002129402,0.000577378,0.0001437711],"domain_scores_gemma":[0.999152,0.00002595079,0.0005414217,0.00002170268,0.0001914147,0.00006747914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002189161,0.00003309354,0.01394722,0.00001654847,0.0000312376,1.919427e-9,0.0001546818,0.00002323909,0.9791093,0.0006504033,0.005959195,0.00005319242],"study_design_scores_gemma":[0.00006331067,0.00001843244,0.04543793,0.00004849261,0.00002445739,0.000003911172,0.00009636401,0.00005034514,0.9526886,0.001083764,0.0004155607,0.00006886887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975598,0.0001687657,0.00001038429,0.001148642,0.0000152959,0.0001264373,0.0003517884,0.000003149919,0.000615712],"genre_scores_gemma":[0.9985991,0.00003986458,0.0006916236,0.0002929822,0.00007924375,0.00001213426,0.000006344887,0.000003834107,0.0002749313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03149071,"threshold_uncertainty_score":0.2617999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02099408313660294,"score_gpt":0.2903333675606695,"score_spread":0.2693392844240665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}