{"id":"W2148168351","doi":"10.1158/1078-0432.ccr-09-2878","title":"Patient-Derived First Generation Xenografts of Non–Small Cell Lung Cancers: Promising Tools for Predicting Drug Responses for Personalized Chemotherapy","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Genome Canada","keywords":"Vinorelbine; Medicine; Gemcitabine; Cisplatin; Docetaxel; Chemotherapy; Oncology; Lung cancer; Regimen; Internal medicine; Cancer; Chemotherapy regimen; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004465168,0.0002594616,0.0003296165,0.0001663116,0.00007940656,0.0003291885,0.0001688731,0.0002032856,0.0009996417],"category_scores_gemma":[0.0004028361,0.0001553637,0.0001707482,0.0001605755,0.0001631351,0.0002447606,0.0001425162,0.0006679358,0.0003220577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935707,"about_ca_system_score_gemma":0.0001664119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003583536,"about_ca_topic_score_gemma":0.0005976246,"domain_scores_codex":[0.9998747,0.00003218356,0.000008592647,0.00002226477,0.00004451131,0.0000178185],"domain_scores_gemma":[0.9997124,0.00008837056,0.00007628189,0.00004038659,0.00002784219,0.00005471069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009428956,0.0002956663,0.02037685,0.00008152065,0.00002987955,0.0001269352,0.00005823424,0.0009758778,0.9667322,0.0001464555,0.0002759837,0.009957529],"study_design_scores_gemma":[0.0002103908,0.0066835,0.1067704,0.0000293432,0.0001574393,0.002823102,0.0001141741,0.0148609,0.8614781,0.0001572135,0.006684361,0.00003095638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904385,0.001626463,0.006516593,0.00007308301,0.00001596725,0.000104176,0.0005260158,0.0001010037,0.0005982212],"genre_scores_gemma":[0.9863791,0.0009903902,0.01059062,0.0000324477,0.000009687958,0.0000635803,0.001309795,0.00001498139,0.0006094743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009996417,"threshold_uncertainty_score":0.003344119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1251946181181474,"score_gpt":0.4642212352664629,"score_spread":0.3390266171483156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}