{"id":"W2148169621","doi":"10.1371/journal.pgen.1002105","title":"Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research Council; Tenovus; Parc Geneteg Cymru; National Cancer Institute; National Institutes of Health; Cancer Research Wales; Cancer Research UK; Wellcome Trust","keywords":"Missing heritability problem; Genome-wide association study; Single-nucleotide polymorphism; Biology; Genetics; Candidate gene; Genetic association; Genetic predisposition; SNP; Bioinformatics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005454957,0.000673574,0.0008446613,0.001298636,0.0002825882,0.000546489,0.0006429033,0.0007337753,0.005200351],"category_scores_gemma":[0.002333123,0.0002663923,0.0006921214,0.001107057,0.0005714704,0.0002602026,0.0005973254,0.0006424375,0.0004956789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002820338,"about_ca_system_score_gemma":0.0002735808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00253301,"about_ca_topic_score_gemma":0.003224612,"domain_scores_codex":[0.9994667,0.00007834645,0.00003906125,0.0002440365,0.0001169605,0.00005488886],"domain_scores_gemma":[0.9989991,0.0004133296,0.0003342714,0.0001331788,0.00004736001,0.00007280656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002534115,0.0001677829,0.7523872,0.0004350315,0.001445901,0.003089133,0.0004808802,0.001572783,0.1775404,0.002521821,0.0007335173,0.05709156],"study_design_scores_gemma":[0.000205987,0.0002934418,0.9669445,0.00007890238,0.0009363396,0.006637607,0.0002962404,0.00452867,0.01389334,0.003556459,0.002593049,0.00003540818],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988356,0.00313227,0.006117523,0.0002654899,0.00002284125,0.00002893745,0.001263537,0.0001395039,0.000673985],"genre_scores_gemma":[0.9945629,0.000682849,0.003628495,0.00007932113,0.00002537084,0.00001367528,0.0005676408,0.00001877943,0.0004209676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005200351,"threshold_uncertainty_score":0.01739693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05720293714755776,"score_gpt":0.2647926086164159,"score_spread":0.2075896714688582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}