{"id":"W2148183823","doi":"10.2337/db13-1005","title":"OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Glibenclamide; Tolbutamide; Sulfonylurea; Internal medicine; Endocrinology; Islet; Insulin; Sulfonylurea receptor; Transporter; Pancreatic islets; Chemistry; Nateglinide; Pharmacology; Diabetes mellitus; Biology; Biochemistry; Type 2 diabetes; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537719,0.0001559328,0.0003702464,0.00003930257,0.00005830689,0.00001501547,0.0001461983,0.00006537198,0.00006775723],"category_scores_gemma":[0.00004782259,0.00007053356,0.0000757813,0.0001976242,0.0002016431,0.00006676517,0.00002779231,0.0001500002,0.000008393169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000117212,"about_ca_system_score_gemma":0.0000222499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000680747,"about_ca_topic_score_gemma":0.00001114159,"domain_scores_codex":[0.999082,0.00009294111,0.0002254979,0.0001796583,0.0001904018,0.0002294924],"domain_scores_gemma":[0.9992036,0.0003344704,0.00009048007,0.0002917602,0.00003974542,0.00004000975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002172727,0.00003173399,0.1149013,0.0002788047,0.00004725587,0.000001992606,0.001148441,0.000001212759,0.8825231,0.00005062187,0.0001190129,0.0008748137],"study_design_scores_gemma":[0.0006303157,0.0001196999,0.2384129,0.0002751537,0.00006280548,2.358112e-7,0.0001385659,0.00006099876,0.7596517,0.0004726385,0.0001126688,0.00006226809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970587,0.0008189168,0.000009151338,0.0008589915,0.00009584358,0.0007870962,0.00001037415,0.00001513641,0.0003457118],"genre_scores_gemma":[0.9990566,0.0001260567,0.00008286399,0.0003386521,0.0000350798,0.0001148088,0.000003597421,0.0000139745,0.0002283706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1235116,"threshold_uncertainty_score":0.2876275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003907114466603237,"score_gpt":0.1981841184137868,"score_spread":0.1942770039471835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}