{"id":"W2148183823","doi":"10.2337/db13-1005","title":"OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Glibenclamide; Tolbutamide; Sulfonylurea; Internal medicine; Endocrinology; Islet; Insulin; Sulfonylurea receptor; Transporter; Pancreatic islets; Chemistry; Nateglinide; Pharmacology; Diabetes mellitus; Biology; Biochemistry; Type 2 diabetes; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267779,0.0002787101,0.0003717012,0.0002068881,0.0001714144,0.0003864379,0.0001361494,0.0002278299,0.001248472],"category_scores_gemma":[0.0001326618,0.0001787116,0.0003575986,0.0002586628,0.0001889064,0.0001711495,0.0001634097,0.0005559098,0.0004946098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735938,"about_ca_system_score_gemma":0.0002142762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306887,"about_ca_topic_score_gemma":0.001148007,"domain_scores_codex":[0.999859,0.00001828203,0.0000164556,0.00002516032,0.00005145276,0.0000296749],"domain_scores_gemma":[0.9998958,0.00001394812,0.00002874185,0.00001324137,0.0000167411,0.00003155771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007844499,0.000007405504,0.0001331822,0.00001225352,0.000003366563,0.00003623569,0.000007972915,0.000007503674,0.9994906,0.00001340276,0.00001430884,0.0001953439],"study_design_scores_gemma":[0.00003832302,0.00036467,0.0302178,0.00001239428,0.00004884487,0.0008436715,0.0001115257,0.001147701,0.9630467,0.00006037729,0.00409858,0.000009438969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950114,0.001695111,0.001594169,0.0001300038,0.00003535891,0.0000136531,0.0003838332,0.00007723746,0.001059281],"genre_scores_gemma":[0.9939569,0.001389598,0.001320162,0.00006648564,0.00001529902,0.00002587768,0.001084,0.00003123713,0.002110411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306887,"threshold_uncertainty_score":0.004176557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003907114466603237,"score_gpt":0.1981841184137868,"score_spread":0.1942770039471835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}