{"id":"W2148186570","doi":"10.1093/hmg/ddv294","title":"Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cégep de Chicoutimi; Université de Sherbrooke; Université du Québec à Chicoutimi; McGill University; University of Toronto; SickKids Foundation; Montreal Neurological Institute and Hospital; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Genetics; Methylation; CpG site; Locus (genetics); Gene; Allele; Linkage disequilibrium; Gene expression; Haplotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000440958,0.0002044421,0.0003357072,0.0001582722,0.00003680494,0.00001360997,0.0001759333,0.0002345046,0.000004237321],"category_scores_gemma":[0.0001425116,0.0002207052,0.00007648001,0.0001548738,0.0001289901,0.000003882304,0.0001231833,0.00008120338,6.968916e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001606049,"about_ca_system_score_gemma":0.00009797525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004118361,"about_ca_topic_score_gemma":0.00004355313,"domain_scores_codex":[0.9981468,0.0002617854,0.000639634,0.0003928712,0.0003120203,0.0002468818],"domain_scores_gemma":[0.9987878,0.00002615659,0.0003314288,0.0004611986,0.0002300134,0.0001633561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003087,0.0001032536,0.05531906,0.00003515111,0.0000316206,0.000001886585,0.000174546,0.004748507,0.938072,0.00002101584,0.000009044888,0.001383645],"study_design_scores_gemma":[0.003077033,0.0008673263,0.08459839,0.00003212888,0.00003157658,0.000001518908,0.00005228214,0.0002960247,0.9100595,0.0006232875,0.0001620661,0.0001988737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560911,0.01709407,0.02621427,0.00002414478,0.00004857363,0.0004114315,0.00004167749,0.000005254328,0.00006945853],"genre_scores_gemma":[0.9900975,0.0005646429,0.009093312,0.00005179401,0.00004851674,0.00002569101,0.00007502463,0.00003706741,0.000006443815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03400638,"threshold_uncertainty_score":0.9000095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04167658675821453,"score_gpt":0.2796153366236914,"score_spread":0.2379387498654769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}