{"id":"W2148186570","doi":"10.1093/hmg/ddv294","title":"Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cégep de Chicoutimi; Université de Sherbrooke; Université du Québec à Chicoutimi; McGill University; University of Toronto; SickKids Foundation; Montreal Neurological Institute and Hospital; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA methylation; Genetics; Methylation; CpG site; Locus (genetics); Gene; Allele; Linkage disequilibrium; Gene expression; Haplotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004668763,0.0004065588,0.0005287719,0.0006952232,0.000328693,0.0003910944,0.0002720252,0.0005857186,0.00203638],"category_scores_gemma":[0.00180481,0.0002087935,0.0003800477,0.000679204,0.0004908057,0.0002646829,0.0004977389,0.0004936706,0.0001717827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002173827,"about_ca_system_score_gemma":0.0001784911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001449588,"about_ca_topic_score_gemma":0.001468353,"domain_scores_codex":[0.9994771,0.0001102293,0.00003740832,0.0002509899,0.00008627376,0.00003810047],"domain_scores_gemma":[0.9993363,0.0001972239,0.0002282617,0.00009095944,0.0000471424,0.0001001121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001866906,0.0001055025,0.8457566,0.0001079677,0.0005864583,0.001286002,0.0008845916,0.0003089902,0.1319754,0.0004413307,0.0001857591,0.01649456],"study_design_scores_gemma":[0.00001629757,0.0001492566,0.9948127,0.000007404309,0.0001079944,0.00158725,0.0001011937,0.0005536221,0.00205732,0.0004736706,0.000122959,0.00001036673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987628,0.0002870773,0.0006167392,0.00003765226,0.00000245653,0.000003385004,0.0001105487,0.00002060639,0.0001586679],"genre_scores_gemma":[0.9991969,0.0000387806,0.0005666185,0.00001218536,0.000004087909,0.000003853817,0.00005437711,0.000004004035,0.0001192524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203638,"threshold_uncertainty_score":0.006812394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04167658675821453,"score_gpt":0.2796153366236914,"score_spread":0.2379387498654769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}