{"id":"W2148191984","doi":"10.1073/pnas.1000556107","title":"Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Canada Research Chairs; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Zinc finger; Ribose; DNA; Poly ADP ribose polymerase; Polynucleotide; Biochemistry; DNA repair; DNA damage; Polymerase; Biology; Binding site; Chemistry; Enzyme; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002237603,0.00005377511,0.0001195916,0.0001837709,0.00005576762,0.000009059351,0.0002000538,0.00007298268,0.00001051336],"category_scores_gemma":[0.0008332836,0.00003298743,0.00002295182,0.0004609675,0.0009737881,0.0002522132,0.00003043987,0.000174577,8.18341e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009810211,"about_ca_system_score_gemma":0.00003263025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004888434,"about_ca_topic_score_gemma":2.478339e-7,"domain_scores_codex":[0.9988337,0.00001627828,0.0003184534,0.0001377433,0.0006331829,0.00006064692],"domain_scores_gemma":[0.9990489,0.0001944735,0.0004528198,0.00001265213,0.0002743796,0.0000168108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001790098,0.0000277059,0.01031936,0.00006994521,0.000004675884,3.095947e-9,0.0008821602,0.000001654766,0.9854485,0.002449834,0.00004622889,0.0005709414],"study_design_scores_gemma":[0.000267327,0.00004187697,0.3659013,0.00006719969,0.000008378304,0.00000998395,0.0003993967,0.0001679779,0.5963078,0.03679168,0.00001676131,0.00002034471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953414,0.00007306843,3.609838e-7,0.004001264,0.00001392387,0.0002164699,0.00005471502,0.000002416578,0.0002963636],"genre_scores_gemma":[0.9992113,0.00002877529,0.000563783,0.0001324515,0.00004053566,0.000006269492,5.085306e-7,0.000002244392,0.0000142062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3891407,"threshold_uncertainty_score":0.3587963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186758828203542,"score_gpt":0.327663995888611,"score_spread":0.2957964076065756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}