{"id":"W2148199584","doi":"10.1002/anie.201504661","title":"Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Sulforhodamine B; Liposome; Chemistry; Biophysics; Ethylene glycol; Cytosol; HeLa; Endosome; Conformational change; Drug delivery; Lipid bilayer; Cationic polymerization; PEG ratio; Biochemistry; Membrane; Cell; Organic chemistry; Cytotoxicity; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736251,0.000343438,0.0001582967,0.0001424336,0.0001108576,0.0003608416,0.0002409303,0.0003367789,0.0006628351],"category_scores_gemma":[0.0001744468,0.0001471953,0.0001774896,0.0001170962,0.0002569991,0.0004157331,0.0003242478,0.0004960619,0.0003417833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424741,"about_ca_system_score_gemma":0.0001661227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002256438,"about_ca_topic_score_gemma":0.0002488714,"domain_scores_codex":[0.9999218,0.00001348417,0.000006394242,0.00001799153,0.00002344853,0.00001676525],"domain_scores_gemma":[0.9999198,0.00001801501,0.00002772707,0.000008555568,0.000009485786,0.00001629575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003984642,0.000009197704,0.00002641168,0.00002882362,0.000002759153,0.00005066617,0.00001483107,0.00008703972,0.9972458,0.0002067129,0.00003881225,0.00224924],"study_design_scores_gemma":[0.00001729994,0.00009249537,0.0001038594,0.000002272598,0.000006243065,0.00008102379,0.000004011177,0.0004844646,0.996723,0.00004142796,0.002437405,0.000006315247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498792,0.003906047,0.04196944,0.0004526276,0.000120594,0.0001285388,0.0002234937,0.0004569078,0.002863102],"genre_scores_gemma":[0.9768436,0.002397328,0.01798414,0.0001561014,0.00002794004,0.00009824818,0.0001485298,0.00009046213,0.002253621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006628351,"threshold_uncertainty_score":0.002217412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04138975073066689,"score_gpt":0.2744739807834753,"score_spread":0.2330842300528085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}