{"id":"W2148247362","doi":"10.1073/pnas.0510197103","title":"<i>Als2</i> -deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Child and Family Research Institute; University of British Columbia","funders":"National Center for Research Resources; Wellcome Trust","keywords":"Endosome; Biology; Cell biology; Pathogenesis; Motor neuron; Transferrin receptor; Endocytosis; Neuron; Neuroscience; Receptor; Transferrin; Endocrinology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576095,0.001460798,0.0005029742,0.001020512,0.0003850583,0.0005612866,0.0003235447,0.000707166,0.005114748],"category_scores_gemma":[0.0001238585,0.0003604675,0.0003749032,0.0003748565,0.0005364569,0.0002698381,0.0003786991,0.0008842845,0.001817123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004398582,"about_ca_system_score_gemma":0.00018106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001168066,"about_ca_topic_score_gemma":0.001845791,"domain_scores_codex":[0.9997509,0.00002711312,0.00003477001,0.00007690088,0.00006754757,0.00004272773],"domain_scores_gemma":[0.9997049,0.00002039774,0.0001175283,0.00001772987,0.00002443209,0.0001149552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007566,0.00004853412,0.0002970272,0.00004493983,0.00001902263,0.0003401406,0.00002653259,0.00006384778,0.9977074,0.0001680298,0.0002638859,0.0008198998],"study_design_scores_gemma":[0.0001691584,0.0005130496,0.0175662,0.00004996768,0.00008804283,0.006039632,0.0001350861,0.001302031,0.9622021,0.0003767753,0.01151884,0.00003900653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799305,0.0009854507,0.005092791,0.0004482112,0.0001051785,0.00005901274,0.006847763,0.001112402,0.005418667],"genre_scores_gemma":[0.9520237,0.001232421,0.008436489,0.0004394177,0.0000661533,0.0001701228,0.009916057,0.0008130685,0.02690252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005114748,"threshold_uncertainty_score":0.01711047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857806238190474,"score_gpt":0.2482474071778572,"score_spread":0.2296693447959525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}