{"id":"W2148253816","doi":"10.1124/mol.106.024778","title":"Structure-Based Identification of Novel Human γ-Glutamylcysteine Synthetase Inhibitors","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"National Cancer Institute","keywords":"Identification (biology); Computational biology; Biology; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003712446,0.0001928008,0.0002135915,0.0001305177,0.00006536752,0.000007009782,0.0002363782,0.0001979375,0.00008712108],"category_scores_gemma":[0.00003539295,0.0001978337,0.0001361997,0.0001510383,0.0001663768,0.000003583981,0.00007724836,0.0001116956,0.000002820007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554942,"about_ca_system_score_gemma":0.00005830839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001587718,"about_ca_topic_score_gemma":0.000009420178,"domain_scores_codex":[0.99861,0.00005692723,0.0004793131,0.000368978,0.0001640228,0.000320768],"domain_scores_gemma":[0.999175,0.00001142435,0.000250647,0.0003190467,0.0001325925,0.0001112987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008515586,0.0001703698,0.0001244251,0.00002566097,0.00007466371,0.00001390913,0.00001427972,0.0007648128,0.9969393,0.0003530208,0.0007524674,0.0006819399],"study_design_scores_gemma":[0.001642027,0.0001293181,0.0006840551,0.000004195204,0.00009820996,0.00001438377,0.00001330923,0.0001239271,0.9863341,0.00002452,0.01074221,0.0001896856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479167,0.000719351,0.05019575,0.00007718066,0.0005370589,0.000259812,0.00006673179,0.00001622733,0.0002111137],"genre_scores_gemma":[0.9978321,0.00000789514,0.0008512724,0.0006083237,0.0002794042,0.00001103492,0.0002357646,0.00003393032,0.0001402381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04991537,"threshold_uncertainty_score":0.8067425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007497278412996604,"score_gpt":0.2895504787969689,"score_spread":0.2820532003839724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}