{"id":"W2148257524","doi":"10.1039/c4pp00292j","title":"Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization","year":2014,"lang":"en","type":"article","venue":"Photochemical & Photobiological Sciences","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; McGill University","funders":"National Center for Research Resources; National Cancer Institute","keywords":"Ceramide synthase; Ceramide; Apoptosis; Cancer research; Head and neck squamous-cell carcinoma; Fumonisin B1; Programmed cell death; Basal cell; Head and neck; Apoptotic cell death; Chemistry; Biology; Medicine; Pathology; Biochemistry; Internal medicine; Head and neck cancer; Cancer; Mycotoxin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411982,0.0003300426,0.0004047413,0.0003316771,0.0003110523,0.0002448687,0.0002629403,0.0002730323,0.002619656],"category_scores_gemma":[0.0001253158,0.0001863311,0.0003421546,0.0003746647,0.0001907593,0.000187288,0.0001577789,0.0006421932,0.0005326307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941242,"about_ca_system_score_gemma":0.0004918072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005217474,"about_ca_topic_score_gemma":0.006427603,"domain_scores_codex":[0.9998786,0.00001796455,0.00001090953,0.00001638495,0.00002206107,0.00005399642],"domain_scores_gemma":[0.9999141,0.00002496947,0.000007971609,0.000015645,0.0000178238,0.00001951141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001361182,0.0002028367,0.0004701079,0.00007209367,0.00002458132,0.0001000522,0.00006312961,0.0001234663,0.9940117,0.00008953652,0.0002069488,0.003274384],"study_design_scores_gemma":[0.00006383385,0.0009032834,0.005060002,0.000005355366,0.00003761165,0.00009218824,0.00006427558,0.0004424527,0.9923822,0.00002275504,0.0009221612,0.000003761135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99638,0.001618716,0.0003239741,0.00006096239,0.00003969809,0.00002737665,0.0003488357,0.00003770538,0.001162819],"genre_scores_gemma":[0.9947909,0.00129189,0.0002812989,0.00002554123,0.000009837276,0.00002833164,0.0006988604,0.000008733466,0.002864667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005217474,"threshold_uncertainty_score":0.01037419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386256675237239,"score_gpt":0.2521244275194722,"score_spread":0.2382618607670998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}