{"id":"W2148272997","doi":"10.1098/rspb.2012.1659","title":"The yield of experimental yeast populations declines during selection","year":2012,"lang":"en","type":"article","venue":"Proceedings of the Royal Society B Biological Sciences","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies; National Science Foundation","keywords":"Ploidy; Biology; Pleiotropy; Adaptation (eye); Selection (genetic algorithm); Saccharomyces cerevisiae; Yield (engineering); Population; Growth rate; Genetics; Yeast; Phenotype; Gene; Demography; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004533469,0.0002989977,0.0003294079,0.0001482199,0.0002407996,0.0003902296,0.0003957751,0.0002653456,0.0009559523],"category_scores_gemma":[0.0009410497,0.0001499199,0.000221966,0.0002459586,0.0002925045,0.0002259898,0.0005190953,0.0007161805,0.0002023213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000387059,"about_ca_system_score_gemma":0.0001540192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004276516,"about_ca_topic_score_gemma":0.0008338971,"domain_scores_codex":[0.9995401,0.0001093312,0.00006322045,0.0001325977,0.0001175794,0.00003717556],"domain_scores_gemma":[0.9987754,0.0005078937,0.0002650549,0.0002393311,0.0001081943,0.0001040981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002355811,0.00008934158,0.003864661,0.00002200141,0.00001751867,0.00003894667,0.00005408489,0.0001987661,0.9930996,0.00008036498,0.00002399709,0.002275167],"study_design_scores_gemma":[0.00003220551,0.001661675,0.03287807,0.000008501052,0.00003842558,0.0002342391,0.00005953549,0.002691467,0.9610792,0.0001631128,0.001136262,0.0000172995],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996721,0.000170071,0.002430973,0.00003551847,0.00000541364,0.00001782722,0.0001982534,0.00003242434,0.0003885664],"genre_scores_gemma":[0.9936355,0.0001880833,0.004004524,0.00007476685,0.000007067252,0.0001093776,0.0007605251,0.0000623917,0.001157714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009559523,"threshold_uncertainty_score":0.003197908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03250105906555636,"score_gpt":0.285021085335679,"score_spread":0.2525200262701227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}