{"id":"W2148297062","doi":"10.1128/mcb.20.2.468-477.2000","title":"Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"EIF4G; EIF4E; Eukaryotic initiation factor; Biology; Eukaryotic translation; eIF4A; Initiation factor; Binding site; Internal ribosome entry site; Binding domain; Eukaryotic Small Ribosomal Subunit; Ribosome; Molecular biology; Biochemistry; Translation (biology); Messenger RNA; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006401024,0.0002006505,0.0002726284,0.0000455073,0.0004311903,0.00003717189,0.0001215268,0.0002505179,0.00001359937],"category_scores_gemma":[0.00004142843,0.0001261929,0.0001326781,0.00006625574,0.0007547224,0.00001153972,0.00002564706,0.0001313261,0.000001943203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000612435,"about_ca_system_score_gemma":0.00004633476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006229021,"about_ca_topic_score_gemma":0.0000410652,"domain_scores_codex":[0.9985076,0.000475467,0.0003338644,0.0003655714,0.0001102217,0.0002073113],"domain_scores_gemma":[0.9992997,0.0001571297,0.0001495094,0.0002841326,0.00005845478,0.00005105324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001382985,0.00003800984,0.0002904484,0.00006078715,0.0001987601,0.000003869984,0.001150178,0.00002819392,0.9723777,0.007122074,0.000007151333,0.0173399],"study_design_scores_gemma":[0.02150638,0.001628639,0.001121148,0.0001955848,0.001382879,0.0005157321,0.001263746,0.003013312,0.9198469,0.03998642,0.008426516,0.001112739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9121811,0.009359729,0.07616532,0.0007910281,0.00007206672,0.001086762,0.00005746036,0.000008808181,0.0002777264],"genre_scores_gemma":[0.9979729,0.0008299686,0.0004121009,0.0002638294,0.00007010269,0.0001184909,0.0001821081,0.00001778875,0.0001327095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0857918,"threshold_uncertainty_score":0.5145998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03489317443944717,"score_gpt":0.2329814707211067,"score_spread":0.1980882962816596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}