{"id":"W2148313388","doi":"10.1074/jbc.m112.398180","title":"Biochemical Mechanism of HIV-1 Resistance to Rilpivirine","year":2012,"lang":"fr","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Rilpivirine; Reverse transcriptase; Protein subunit; Chemistry; Dodecameric protein; Etravirine; Mutant; Biophysics; Stereochemistry; Molecular biology; Human immunodeficiency virus (HIV); Biology; Biochemistry; DNA; Virology; Antiretroviral therapy; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000695899,0.0002801298,0.0007687777,0.00004905011,0.00003446483,0.000007294449,0.0002304545,0.0004003715,0.001846113],"category_scores_gemma":[0.000662684,0.0001936597,0.0003117397,0.0002395977,0.0001753807,0.00006708496,0.0001156536,0.0004363144,0.0001420046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002709393,"about_ca_system_score_gemma":0.0001382948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.955459e-7,"about_ca_topic_score_gemma":8.252871e-8,"domain_scores_codex":[0.997874,0.00005345126,0.000924811,0.0001882829,0.0003726148,0.0005868245],"domain_scores_gemma":[0.9981127,0.0001908558,0.0004694485,0.0002118623,0.0002321859,0.0007829352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008920227,0.001844571,0.01727249,0.0004893218,0.0004818438,0.0002318677,0.0003113895,6.415144e-7,0.9258258,0.0008662583,0.05054482,0.001238983],"study_design_scores_gemma":[0.001278381,0.0001574084,0.002029592,0.0009418882,0.0002065529,0.000336477,0.0002254928,0.000001459516,0.8934994,0.0002754385,0.1008489,0.000199055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439564,0.03304823,0.0006157709,0.01197755,0.0007891521,0.0001573018,0.0000591792,0.0000129147,0.009383505],"genre_scores_gemma":[0.9457689,0.001095731,0.01110323,0.0001650262,0.002039724,0.000003741789,0.00001818172,0.00001554738,0.03978996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05030406,"threshold_uncertainty_score":0.9990664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02304571889362739,"score_gpt":0.2689273936086486,"score_spread":0.2458816747150213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}