{"id":"W2148356388","doi":"10.1086/653112","title":"Improving the Immunogenicity of Pneumococcal Conjugate Vaccine in HIV‐Infected Adults with a Toll‐Like Receptor 9 Agonist Adjuvant: A Randomized, Controlled Trial","year":2010,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"","keywords":"Medicine; Immunogenicity; Adjuvant; Pneumococcal conjugate vaccine; Agonist; Toll-like receptor; Virology; Streptococcus pneumoniae; Immunology; Conjugate; Receptor; Antibody; Internal medicine; Microbiology; Immune system; Antibiotics; Biology; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001653351,0.0004392194,0.003044322,0.0002210822,0.0002769745,0.00005746541,0.0002025071,0.0003545989,0.000302082],"category_scores_gemma":[0.008183646,0.000236458,0.001445292,0.0004944172,0.0009327008,0.0001270562,0.00009542545,0.001330388,0.00004218571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000053653,"about_ca_system_score_gemma":0.0007680495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001782431,"about_ca_topic_score_gemma":0.0007389805,"domain_scores_codex":[0.9953197,0.001069157,0.00218758,0.0005904283,0.0003625408,0.0004705569],"domain_scores_gemma":[0.992865,0.004526296,0.0009504888,0.0007939313,0.0004626871,0.0004015635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8070758,0.003947902,0.1783625,0.0001020243,0.0007856431,0.00004161202,0.0000729255,0.00001299131,0.008257818,0.0001052209,0.0000915224,0.001144026],"study_design_scores_gemma":[0.9109371,0.002700116,0.08278786,0.0002045358,0.001654711,0.00004487038,0.00004658696,0.0006593574,0.0001405692,0.00004772071,0.0004895928,0.0002869689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885719,0.0002125671,0.00006971649,0.0006328552,0.001880585,0.007872538,0.00006109595,0.000216686,0.0004820672],"genre_scores_gemma":[0.9969752,0.0001773546,0.000008074389,0.0005920317,0.0007478366,0.001291502,0.00004409295,0.00005000292,0.0001138941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1038613,"threshold_uncertainty_score":0.9797179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008902687124246841,"score_gpt":0.2897091365054948,"score_spread":0.280806449381248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}