{"id":"W2148356388","doi":"10.1086/653112","title":"Improving the Immunogenicity of Pneumococcal Conjugate Vaccine in HIV‐Infected Adults with a Toll‐Like Receptor 9 Agonist Adjuvant: A Randomized, Controlled Trial","year":2010,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"","keywords":"Medicine; Immunogenicity; Adjuvant; Pneumococcal conjugate vaccine; Agonist; Toll-like receptor; Virology; Streptococcus pneumoniae; Immunology; Conjugate; Receptor; Antibody; Internal medicine; Microbiology; Immune system; Antibiotics; Biology; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003012539,0.001355014,0.003274308,0.0004721288,0.0006015274,0.001147002,0.00109811,0.002653346,0.00505678],"category_scores_gemma":[0.002712518,0.0006871127,0.002140603,0.0005568117,0.001280394,0.0008577487,0.0003849117,0.00217245,0.0006282296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005739491,"about_ca_system_score_gemma":0.001324791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007851674,"about_ca_topic_score_gemma":0.001251715,"domain_scores_codex":[0.9987124,0.0007587741,0.00012039,0.0001910674,0.00009716976,0.0001202613],"domain_scores_gemma":[0.9984645,0.0005960741,0.0004036096,0.0001039239,0.0001213448,0.0003106136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9853694,0.003437034,0.0004349585,0.0009994233,0.00103524,0.00002231745,0.00002624309,0.0001080613,0.001023631,0.00004473569,0.0003019857,0.007197142],"study_design_scores_gemma":[0.9645469,0.03358564,0.0007422367,0.00004968836,0.0004901734,0.00001276223,0.000009406287,0.0001292612,0.0001622759,0.00004073645,0.0002251684,0.000005886534],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720524,0.01488591,0.0008629623,0.001059868,0.001247596,0.007241385,0.001049009,0.0001332298,0.001467659],"genre_scores_gemma":[0.9717008,0.009010052,0.00252018,0.001926626,0.001222063,0.01070437,0.0009568175,0.00002340696,0.001935566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00505678,"threshold_uncertainty_score":0.01691657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008902687124246841,"score_gpt":0.2897091365054948,"score_spread":0.280806449381248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}