{"id":"W2148412022","doi":"10.1128/aac.01794-09","title":"Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Natamycin; Nystatin; Ergosterol; Vacuole; Biology; Polyene; Biochemistry; Microbiology; Chemistry; Antibiotics; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007771324,0.0001493657,0.00009668861,0.00002160828,0.0001942402,0.00004013859,0.00008323575,0.0001056666,0.0001853655],"category_scores_gemma":[8.969046e-7,0.0001007184,0.00005175475,0.00004579941,0.00007863263,0.000008594733,0.00003103142,0.0001268835,0.000007251043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006277352,"about_ca_system_score_gemma":0.00001038937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002588927,"about_ca_topic_score_gemma":0.0002526639,"domain_scores_codex":[0.9993362,0.00001411026,0.0001320066,0.0002826314,0.00007708734,0.0001579097],"domain_scores_gemma":[0.9996424,0.000003303311,0.00006958571,0.0002063504,0.00003274842,0.00004564962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000595627,0.0001062475,0.002257928,0.000008847454,0.00002710584,0.00000292249,0.0002020994,0.00000140171,0.9803864,0.000002080187,0.001429631,0.01497969],"study_design_scores_gemma":[0.001686995,0.0001579346,0.002508695,0.00001355423,0.00001074618,0.00006156955,0.00001990265,0.00003837424,0.7014655,0.000002062496,0.2939074,0.0001272482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962183,0.00003591486,0.002501674,0.0006868392,0.0001817783,0.0002156949,0.000009385282,0.00001005733,0.0001404193],"genre_scores_gemma":[0.9959361,0.0006761273,0.0001292386,0.001665115,0.000223151,0.000004529333,0.0008072442,0.00002534254,0.0005331784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2924778,"threshold_uncertainty_score":0.4107179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007437222624885196,"score_gpt":0.2333261714964244,"score_spread":0.2258889488715392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}