{"id":"W2148412022","doi":"10.1128/aac.01794-09","title":"Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergosterol","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Natamycin; Nystatin; Ergosterol; Vacuole; Biology; Polyene; Biochemistry; Microbiology; Chemistry; Antibiotics; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243101,0.000508565,0.0003605723,0.000160188,0.0001027367,0.0002393256,0.0002764123,0.0003799095,0.0009452295],"category_scores_gemma":[0.000167812,0.0001356051,0.0003093221,0.0001136049,0.0001929727,0.0001804757,0.0002384278,0.0004836741,0.0004950456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000301413,"about_ca_system_score_gemma":0.0001656836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004280195,"about_ca_topic_score_gemma":0.0006331598,"domain_scores_codex":[0.9998215,0.00005012662,0.00002520486,0.00002476563,0.00004351568,0.00003498121],"domain_scores_gemma":[0.9998296,0.00005487942,0.00004631648,0.00002441098,0.00001792445,0.00002674293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000564032,0.000006916081,0.00004239369,0.00002204654,0.000002781433,0.00001952243,0.000003531644,0.00002065066,0.9995559,0.00002107029,0.000009060973,0.0002398958],"study_design_scores_gemma":[0.00001189195,0.000215322,0.001989204,0.00000385827,0.000009040562,0.0001602122,0.000007076333,0.0003430869,0.9964287,0.00001790998,0.0008108662,0.000002989931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902912,0.003730388,0.003393345,0.0001325082,0.00006328741,0.0000459363,0.0003250689,0.0001003836,0.00191803],"genre_scores_gemma":[0.9942741,0.001428036,0.001873738,0.00007336897,0.00001656041,0.00004442357,0.0004446888,0.00002064474,0.001824538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009452295,"threshold_uncertainty_score":0.003162146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007437222624885196,"score_gpt":0.2333261714964244,"score_spread":0.2258889488715392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}