{"id":"W2148416586","doi":"10.1124/jpet.102.034744","title":"Persistent Suppression of Hepatic CYP2A1 Expression and Serum Triiodothyronine Levels by Tamoxifen in Intact Female Rats: Dose-Response Analysis and Comparison with 4-Hydroxytamoxifen, Fulvestrant (ICI 182,780), and 17β-Estradiol-3-benzoate","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Tamoxifen; Endocrinology; Internal medicine; Triiodothyronine; Dose; CYP3A; Antiestrogen; Metabolite; Chemistry; Hormone; Biology; Medicine; Breast cancer; Cytochrome P450; Metabolism; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075331,0.000857349,0.001186615,0.001152379,0.0003437329,0.0004811615,0.0004344269,0.000758374,0.002138392],"category_scores_gemma":[0.0004401856,0.0006019332,0.000703452,0.0006332102,0.0007602419,0.0007529526,0.0002221724,0.001332448,0.0006207435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005623641,"about_ca_system_score_gemma":0.0004817161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001606547,"about_ca_topic_score_gemma":0.003322404,"domain_scores_codex":[0.9995844,0.00004842338,0.00003779166,0.0001030622,0.00008521422,0.0001411161],"domain_scores_gemma":[0.9991919,0.00009093633,0.0002283733,0.0001517549,0.00008265874,0.0002543176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006517852,0.0003050196,0.000659684,0.00003160022,0.0000286933,0.00007229509,0.00003710407,0.0000829106,0.9897838,0.00004847181,0.00007610808,0.002356485],"study_design_scores_gemma":[0.0001684486,0.004243558,0.006562092,0.000003721127,0.00008884121,0.0001660141,0.00006173342,0.0004789069,0.9874698,0.00004919968,0.0006918073,0.00001583482],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995504,0.001340029,0.001480487,0.0001581357,0.00006423258,0.00003036607,0.000877082,0.0001640954,0.0003816192],"genre_scores_gemma":[0.9865875,0.001262579,0.002010682,0.00009616984,0.00006205829,0.0001618391,0.00181942,0.00009389962,0.007905938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138392,"threshold_uncertainty_score":0.00715369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874316733160798,"score_gpt":0.2985538789808309,"score_spread":0.2798107116492229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}