{"id":"W2148430681","doi":"10.1021/bm1008074","title":"Protein Specificity of Charged Sequences in Polyanions and Heparins","year":2010,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Francis Xavier University","funders":"Division of Chemistry; Advanced Foods and Materials Network; National Science Foundation","keywords":"Chemistry; Electrostatics; Sulfation; Static electricity; Heparinoid; Charge density; Biophysics; Binding selectivity; Intrinsically disordered proteins; Chemical physics; Computational chemistry; Biochemistry; Heparin; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009337,0.0001245148,0.0001404782,0.00009759861,0.00004958038,0.00002039793,0.0002022608,0.000141647,0.00003186357],"category_scores_gemma":[0.00007952036,0.0001128422,0.00004352578,0.0001316036,0.0002916035,0.00000409635,0.0001307914,0.0001321174,0.000003585915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004816744,"about_ca_system_score_gemma":0.00008933855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435931,"about_ca_topic_score_gemma":0.00206212,"domain_scores_codex":[0.9990602,0.00004826693,0.000194292,0.0003076118,0.0001352595,0.0002543383],"domain_scores_gemma":[0.9995247,0.000006362603,0.0000533046,0.0002750803,0.00005238601,0.00008822319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005456225,0.00007566247,0.007287285,0.00002237608,0.00001130271,0.00001163159,0.00003014333,1.187793e-7,0.9879828,0.001324095,0.0000320511,0.003167972],"study_design_scores_gemma":[0.0003467978,0.0001771738,0.0183591,0.00001355242,0.000002102439,0.00002437651,0.00002805482,0.00002414185,0.976782,0.0003574328,0.003747288,0.0001379437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976714,0.0003712361,0.0001237137,0.0001762601,0.00005518604,0.0003113022,0.00006337741,0.000006890682,0.001220656],"genre_scores_gemma":[0.9981164,0.00006607314,0.001444425,0.00001691486,0.00005748094,0.00004111621,0.00003296606,0.00001276608,0.0002118631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01120076,"threshold_uncertainty_score":0.4601571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105925121411284,"score_gpt":0.2661181274729272,"score_spread":0.2555256153317988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}