{"id":"W2148430681","doi":"10.1021/bm1008074","title":"Protein Specificity of Charged Sequences in Polyanions and Heparins","year":2010,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Francis Xavier University","funders":"Division of Chemistry; Advanced Foods and Materials Network; National Science Foundation","keywords":"Chemistry; Electrostatics; Sulfation; Static electricity; Heparinoid; Charge density; Biophysics; Binding selectivity; Intrinsically disordered proteins; Chemical physics; Computational chemistry; Biochemistry; Heparin; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331921,0.0001833846,0.0001423384,0.0001140829,0.0001732603,0.0003222619,0.0001691969,0.0002308571,0.000631229],"category_scores_gemma":[0.0003821769,0.0001450977,0.0001235903,0.00009457032,0.0003624895,0.0001979915,0.0001863476,0.0002002054,0.0002246986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275101,"about_ca_system_score_gemma":0.0001903235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005689467,"about_ca_topic_score_gemma":0.0009505484,"domain_scores_codex":[0.9998162,0.00004428279,0.000009155122,0.00003345692,0.00006069172,0.00003618008],"domain_scores_gemma":[0.9998224,0.00007490865,0.0000317766,0.000009029114,0.00002268121,0.00003922371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008274597,0.00001168741,0.0007672424,0.00002732808,0.000006898421,0.00004278414,0.00002368432,0.0009895773,0.9961397,0.0005062214,0.00001664619,0.001385417],"study_design_scores_gemma":[0.00001448031,0.0001933211,0.005432351,0.000005365883,0.00001498636,0.0001654011,0.00003681509,0.008458167,0.9844935,0.0003433507,0.0008305312,0.00001171434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970619,0.0002151194,0.001712899,0.00002052125,0.000004125259,0.000008213093,0.0000112097,0.00001305448,0.0009530475],"genre_scores_gemma":[0.9986364,0.0001061783,0.0008304622,0.00002571808,0.000001809344,0.000006157582,0.00001875488,0.000005379032,0.0003692041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000631229,"threshold_uncertainty_score":0.002111733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105925121411284,"score_gpt":0.2661181274729272,"score_spread":0.2555256153317988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}