{"id":"W2148455734","doi":"10.1038/nmeth812","title":"High-throughput screening of effective siRNAs from RNAi libraries delivered via bacterial invasion","year":2005,"lang":"en","type":"article","venue":"Nature Methods","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"","keywords":"RNA interference; Small interfering RNA; Biology; Gene silencing; Computational biology; Small hairpin RNA; Transfection; Cell biology; Gene; RNA; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001261731,0.001047815,0.0009802828,0.000955142,0.0005403651,0.000909597,0.0006498515,0.0007743159,0.001591644],"category_scores_gemma":[0.0007407785,0.0005410335,0.0007301706,0.0006811782,0.0003585838,0.0003447123,0.0005035021,0.0009928908,0.0009509342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007199174,"about_ca_system_score_gemma":0.0004171489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006919921,"about_ca_topic_score_gemma":0.002367245,"domain_scores_codex":[0.9990076,0.0001689692,0.0001037136,0.0001199612,0.0004807712,0.0001189413],"domain_scores_gemma":[0.9995265,0.0002255107,0.00006646233,0.00004429225,0.00008518166,0.00005199002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004213023,0.00004681219,0.00005988302,0.00004954095,0.000009082542,0.00002870677,0.00001030455,0.0001638467,0.9984394,0.00005659287,0.00007178893,0.001021984],"study_design_scores_gemma":[0.00002310583,0.0001614658,0.0006447569,0.000002972575,0.00002542088,0.00007901007,0.000008913632,0.001421677,0.9967429,0.0000297915,0.0008530037,0.000007095014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094315,0.002999939,0.07594666,0.0003541495,0.0001012433,0.001239923,0.003627788,0.001349345,0.004949321],"genre_scores_gemma":[0.9068928,0.002671436,0.07038152,0.0002110671,0.00003417738,0.0008060127,0.008182184,0.0004450972,0.01037572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591644,"threshold_uncertainty_score":0.00667274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019023542230463,"score_gpt":0.3044577189675658,"score_spread":0.2942674835452612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}