{"id":"W2148501245","doi":"10.1136/ard.2011.152496","title":"MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes","year":2011,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health","keywords":"Anakinra; Medicine; Canakinumab; Macrophage activation syndrome; Monocytosis; Immunology; Internal medicine; Gastroenterology; Erythrocyte sedimentation rate; Arthritis; Bone marrow; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005377762,0.0004347517,0.0004155508,0.001265927,0.0002021684,0.0005437824,0.000216051,0.0007474618,0.0009292999],"category_scores_gemma":[0.001441936,0.0002789603,0.0001935449,0.0003792622,0.0003565251,0.0004315657,0.0003582481,0.0005356026,0.0002431946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858409,"about_ca_system_score_gemma":0.00007587842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001295469,"about_ca_topic_score_gemma":0.0001688058,"domain_scores_codex":[0.9995757,0.0001397904,0.00005171732,0.00006863825,0.0001115018,0.00005265283],"domain_scores_gemma":[0.9992805,0.000213054,0.0002532814,0.00003902988,0.0001139621,0.0001002091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006168846,0.0001503951,0.2351167,0.0004771149,0.0002366045,0.003068054,0.000355406,0.0003788765,0.7119756,0.0004990631,0.000689427,0.04088385],"study_design_scores_gemma":[0.0002357003,0.002205337,0.7866932,0.00008444831,0.0002789048,0.01786592,0.0002955093,0.00309558,0.1842374,0.001214208,0.003727904,0.00006588769],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907781,0.005685735,0.002117753,0.0001278378,0.00005080975,0.00002227906,0.0001957726,0.00004638946,0.0009753062],"genre_scores_gemma":[0.9967109,0.0006231198,0.001918571,0.00005994902,0.00004316476,0.00002897826,0.0001494298,0.000009806027,0.000456101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265927,"threshold_uncertainty_score":0.003108799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.032360766098911,"score_gpt":0.2506443220662226,"score_spread":0.2182835559673116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}