{"id":"W2148507573","doi":"10.1093/hmg/ddl428","title":"Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"Health Research Council of New Zealand; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Cancer Society of New Zealand","keywords":"PKD1; Biology; Mesenchyme; Polycystic kidney disease; Mutant; Autosomal dominant polycystic kidney disease; Cyst; Kidney; Endocrinology; Cell biology; Internal medicine; Apoptosis; Molecular biology; Cancer research; Epithelium; Gene; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460634,0.000268935,0.0002897379,0.0005955081,0.0001888054,0.0003198034,0.0001454599,0.0004080645,0.001120928],"category_scores_gemma":[0.0002785414,0.0002849868,0.0002054272,0.0001996975,0.0004227581,0.000203431,0.000284029,0.0004171157,0.0002094073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772398,"about_ca_system_score_gemma":0.0001447385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750754,"about_ca_topic_score_gemma":0.0008081541,"domain_scores_codex":[0.9997609,0.00004730875,0.00003201113,0.00006570462,0.00005706039,0.00003696664],"domain_scores_gemma":[0.9998041,0.0000629664,0.00005170788,0.00001489262,0.000009424754,0.00005688681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706466,0.00002489489,0.001547932,0.00002282495,0.00000695746,0.0002717233,0.00002864286,0.00006766493,0.9966271,0.00008157895,0.00002870559,0.001021293],"study_design_scores_gemma":[0.00007694211,0.0005728384,0.06725141,0.00001332049,0.00008815973,0.004473905,0.0001326181,0.001733128,0.9230907,0.0002143821,0.002326088,0.000026551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978786,0.0007662477,0.000489744,0.00004379647,0.00001355883,0.0000105854,0.000170471,0.00002519223,0.0006019785],"genre_scores_gemma":[0.9977875,0.00056669,0.0005057232,0.00002993133,0.000006631598,0.00002164947,0.0001670133,0.00002197801,0.0008928039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120928,"threshold_uncertainty_score":0.003749847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004857604394391834,"score_gpt":0.2293039704556297,"score_spread":0.2244463660612379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}