{"id":"W2148507573","doi":"10.1093/hmg/ddl428","title":"Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital","funders":"Health Research Council of New Zealand; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Cancer Society of New Zealand","keywords":"PKD1; Biology; Mesenchyme; Polycystic kidney disease; Mutant; Autosomal dominant polycystic kidney disease; Cyst; Kidney; Endocrinology; Cell biology; Internal medicine; Apoptosis; Molecular biology; Cancer research; Epithelium; Gene; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001023218,0.0003174914,0.0002315949,0.0001245328,0.0001301343,0.00004777672,0.000340028,0.0002266052,0.00002324717],"category_scores_gemma":[0.00002848102,0.0003004408,0.000181134,0.0002019063,0.0001899331,0.000003698867,0.0001378263,0.000132185,0.00001951307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000418568,"about_ca_system_score_gemma":0.000211858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001644388,"about_ca_topic_score_gemma":0.00005372832,"domain_scores_codex":[0.9980987,0.0001016464,0.0004239727,0.0005908023,0.0002807081,0.0005041416],"domain_scores_gemma":[0.999008,0.000004686083,0.0001176351,0.0005243155,0.00005539533,0.000289976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150851,0.0001030038,0.009836203,0.00003361631,0.00004479932,0.0003053987,0.00001538289,0.006495265,0.9821585,0.0001368816,0.0004900818,0.0002657286],"study_design_scores_gemma":[0.001863006,0.0002790186,0.1650009,0.00008673793,0.0001373974,0.00004157401,0.00001513915,0.0002762532,0.8191602,0.001135446,0.01120536,0.0007989246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989442,0.008208123,0.0009424145,0.0001224795,0.0001579571,0.000265252,0.00004449601,0.00001934661,0.0007979114],"genre_scores_gemma":[0.9973608,0.0003460064,0.0005497093,0.0005076483,0.0002299546,0.00005075915,0.0002990091,0.00005494341,0.0006011406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1629983,"threshold_uncertainty_score":0.9999447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004857604394391834,"score_gpt":0.2293039704556297,"score_spread":0.2244463660612379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}