{"id":"W2148557985","doi":"10.1165/rcmb.4818","title":"Phosphodiesterase 4 Inhibitor Cilomilast Inhibits Fibroblast-Mediated Collagen Gel Degradation Induced by Tumor Necrosis Factor- <b>α</b> and Neutrophil Elastase","year":2002,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Elastase; Neutrophil elastase; Tumor necrosis factor alpha; Matrix metalloproteinase; Extracellular matrix; Phosphodiesterase inhibitor; Fibroblast; Chemistry; Enzyme inhibitor; Roflumilast; Matrix metalloproteinase inhibitor; Molecular biology; Pharmacology; Biochemistry; Immunology; Biology; Enzyme; Internal medicine; Inflammation; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163235,0.0004293679,0.0003801695,0.0003041629,0.0001095776,0.0002825751,0.000207708,0.0003001805,0.0007895496],"category_scores_gemma":[0.0001615513,0.0001418344,0.0002764801,0.0001287218,0.0001440144,0.0001371965,0.00008640311,0.0005716488,0.0001899826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254591,"about_ca_system_score_gemma":0.0002624247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005567062,"about_ca_topic_score_gemma":0.001448028,"domain_scores_codex":[0.9998773,0.00002999628,0.00001692214,0.00001347784,0.00002656657,0.00003565662],"domain_scores_gemma":[0.9998879,0.00002259004,0.00004253772,0.000005746427,0.000009996841,0.00003118784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007984284,0.0001842999,0.0001950637,0.0001263549,0.00001694608,0.00008661797,0.000006804537,0.00006130704,0.993676,0.00002283702,0.0001200347,0.004705239],"study_design_scores_gemma":[0.0003413722,0.004661001,0.01033579,0.00001968814,0.00006575558,0.0006169314,0.00002283551,0.001575621,0.9796723,0.00002644599,0.002652568,0.000009692115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839887,0.01166046,0.001793141,0.0001962925,0.0001429626,0.00007340343,0.0003018569,0.0001630565,0.001680061],"genre_scores_gemma":[0.9878613,0.004765393,0.004155449,0.000174338,0.00007850824,0.0001088186,0.0006471181,0.00002107629,0.002187887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007895496,"threshold_uncertainty_score":0.00264132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828503657361012,"score_gpt":0.2186188528206794,"score_spread":0.2103338162470693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}