{"id":"W2148590222","doi":"10.1261/rna.1514909","title":"Structure of the cytosine–cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin","year":2009,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Paromomycin; Cytosine; Biology; RNA; Wobble base pair; Binding site; Nucleic acid structure; Base pair; Isothermal titration calorimetry; Biophysics; Aptamer; Molecular biology; Cytidine; Aminoglycoside; DNA; Biochemistry; Transfer RNA; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002334179,0.0001238602,0.0001850638,0.00006275414,0.00008083517,0.00002028292,0.0002244233,0.00007762311,0.0000119341],"category_scores_gemma":[0.00004590123,0.00005658078,0.00008343619,0.0003725832,0.0000474165,0.000006693213,0.00003302435,0.0001109731,3.211656e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006474054,"about_ca_system_score_gemma":0.00001519978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004182324,"about_ca_topic_score_gemma":0.0001819028,"domain_scores_codex":[0.9991769,0.0001812601,0.0001873843,0.0001773438,0.0001519682,0.0001251979],"domain_scores_gemma":[0.9993315,0.00004461649,0.0002084261,0.0003581005,0.00003929774,0.0000180427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001156228,0.0000238911,0.001151453,0.00001144833,0.0001268509,0.000001386083,0.0003398539,0.0002159878,0.9948353,0.00002805162,0.00003266217,0.003117475],"study_design_scores_gemma":[0.0001664622,0.0001352907,0.0230448,0.00005309206,0.0002596724,0.00001188314,0.0002141774,0.0001708513,0.9755486,0.00002984431,0.000287639,0.00007767718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980574,0.0005777893,0.0001508374,0.0008167384,0.00002387335,0.0002149186,0.0000420403,0.000002130303,0.0001142325],"genre_scores_gemma":[0.999486,0.0001437345,0.00009102246,0.000167481,0.00002979419,0.000003886294,0.00002089195,0.000006562446,0.00005064234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02189335,"threshold_uncertainty_score":0.2307297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007725718461367446,"score_gpt":0.2320514962613125,"score_spread":0.2243257777999451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}