{"id":"W2148606668","doi":"10.2337/diabetes.53.suppl_3.s205","title":"Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R–Dependent Glucose Homeostasis In Vivo","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canada Research Chairs; Canadian Diabetes Association","keywords":"Internal medicine; Endocrinology; Ex vivo; Glucagon-like peptide 1 receptor; Glucagon; Glucose homeostasis; Insulin; Receptor; Glucagon-like peptide-1; Biology; Chemistry; Type 2 diabetes; Medicine; Agonist; Insulin resistance; Diabetes mellitus; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000421808,0.0005166868,0.0008131975,0.0006447564,0.000101261,0.000100146,0.0002223955,0.0002125011,0.0001172057],"category_scores_gemma":[0.0002457185,0.0004278016,0.0001535484,0.0006639722,0.0001028644,0.0002497474,0.0001922451,0.0002565173,0.0002239706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001573802,"about_ca_system_score_gemma":0.0001876996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951772,"about_ca_topic_score_gemma":0.0006260098,"domain_scores_codex":[0.9968314,0.0001135678,0.0006349466,0.0008414474,0.0005246993,0.001053933],"domain_scores_gemma":[0.9986923,0.0001049761,0.0001606655,0.0006097993,0.000149543,0.0002826699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002860464,0.001157219,0.02571089,0.0004674598,0.000282251,0.0003462596,0.001033741,0.0002899792,0.8829327,0.000103936,0.0001598712,0.08722971],"study_design_scores_gemma":[0.005147234,0.001270287,0.01705897,0.0005116976,0.0001621372,0.000002643507,0.0002464097,0.00006187279,0.9739396,0.0002303374,0.0008687072,0.0005000845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907261,0.002000858,0.00002234593,0.004094567,0.0004190514,0.002097711,0.0001611304,0.0001958677,0.0002824078],"genre_scores_gemma":[0.9953433,0.0004044274,0.00119892,0.0008467599,0.0002632028,0.0004538849,0.0003357393,0.00008629742,0.001067426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09100698,"threshold_uncertainty_score":0.9998174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009064261146641871,"score_gpt":0.2327377417239599,"score_spread":0.223673480577318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}