{"id":"W2148606668","doi":"10.2337/diabetes.53.suppl_3.s205","title":"Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R–Dependent Glucose Homeostasis In Vivo","year":2004,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Canada Research Chairs; Canadian Diabetes Association","keywords":"Internal medicine; Endocrinology; Ex vivo; Glucagon-like peptide 1 receptor; Glucagon; Glucose homeostasis; Insulin; Receptor; Glucagon-like peptide-1; Biology; Chemistry; Type 2 diabetes; Medicine; Agonist; Insulin resistance; Diabetes mellitus; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107522,0.0005633209,0.0005538112,0.0002329361,0.0001545052,0.0004744894,0.0003533994,0.000411239,0.002408751],"category_scores_gemma":[0.0001955171,0.0003144949,0.0004910755,0.0001697471,0.0004258594,0.0004673839,0.0002545095,0.002039358,0.0007457145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747083,"about_ca_system_score_gemma":0.0002279022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005592862,"about_ca_topic_score_gemma":0.0008039951,"domain_scores_codex":[0.9997115,0.00003558921,0.00002727572,0.00007050206,0.00006730447,0.0000877995],"domain_scores_gemma":[0.9997467,0.00004477676,0.00006226409,0.00005381144,0.00001858085,0.00007386686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004482131,0.000145352,0.00005962674,0.00002044751,0.000005879977,0.00003289292,0.00001378593,0.00002616796,0.998726,0.00003237145,0.00004259698,0.0004467992],"study_design_scores_gemma":[0.00007473763,0.002357178,0.005829281,0.00001031453,0.00002655864,0.0002299584,0.00005650308,0.0006243536,0.9894249,0.00005142505,0.001305813,0.000008941431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964756,0.0008784171,0.001049013,0.0001291496,0.00005867795,0.00002723654,0.000371784,0.00006892983,0.0009410712],"genre_scores_gemma":[0.991641,0.000944557,0.001248986,0.0001738491,0.00003066785,0.0001102425,0.001281304,0.00004545361,0.004523838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408751,"threshold_uncertainty_score":0.008058071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009064261146641871,"score_gpt":0.2327377417239599,"score_spread":0.223673480577318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}