{"id":"W2148619961","doi":"10.15586/jcbmr.2015.3","title":"Disparity of outcomes: the limits of modeling amyotrophic lateral sclerosis in murine models and translating results clinically","year":2015,"lang":"en","type":"article","venue":"Journal of Controversies in Biomedical Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; SOD1; Clinical trial; Medicine; Disease; Population; Intensive care medicine; Etiology; Drug development; Bioinformatics; Neuroscience; Pathology; Psychology; Biology; Psychiatry; Drug; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.06735601,0.001114923,0.002154694,0.001208778,0.0009113246,0.006494512,0.003768549,0.004415707,0.003901611],"category_scores_gemma":[0.08752668,0.0005109415,0.001452042,0.0009766202,0.006304798,0.008216522,0.004392814,0.009096717,0.001806734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002301594,"about_ca_system_score_gemma":0.005642273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001371783,"about_ca_topic_score_gemma":0.001308817,"domain_scores_codex":[0.977874,0.01324101,0.002393249,0.001908921,0.004027704,0.0005552245],"domain_scores_gemma":[0.9171075,0.06544832,0.003557008,0.005878469,0.006736707,0.001272046],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00105918,0.0004011266,0.004191126,0.0137436,0.0008076072,0.0006753182,0.001400293,0.003022976,0.008158488,0.2909147,0.06571454,0.6099111],"study_design_scores_gemma":[0.0002534328,0.001681933,0.003405785,0.01649567,0.0009642774,0.00122595,0.001379307,0.002457842,0.00703691,0.3155123,0.6493708,0.0002157912],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01117832,0.5853624,0.0915718,0.2690609,0.01251566,0.0006192569,0.0015961,0.0008312526,0.02726432],"genre_scores_gemma":[0.1313415,0.6553814,0.08585859,0.1019971,0.01576253,0.00309228,0.001446395,0.0008995269,0.004220618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.932644,"threshold_uncertainty_score":0.3562168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3034189456163247,"score_gpt":0.4459388272042666,"score_spread":0.1425198815879419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}