{"id":"W2148632293","doi":"10.1093/clinchem/48.8.1147","title":"Cancer Biomarkers: Easier Said Than Done","year":2002,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Biomarker; Biomarker discovery; Cancer biomarkers; Standardization; Cancer; Terminology; Medicine; Bioinformatics; Computer science; Biology; Internal medicine; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000209279,0.0001429535,0.0003732192,0.0000107106,0.00003463399,0.0000124472,0.0001009299,0.0001916475,0.01126536],"category_scores_gemma":[0.0002201151,0.0001199859,0.0003006007,0.000141163,0.0001756686,0.00002717172,0.0000475007,0.0003071953,0.0001835509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006035963,"about_ca_system_score_gemma":0.00005617962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003720572,"about_ca_topic_score_gemma":0.000005385121,"domain_scores_codex":[0.9987199,0.00001594121,0.0004303201,0.0003692928,0.0002007681,0.000263718],"domain_scores_gemma":[0.9989355,0.0001004939,0.00009443176,0.000437826,0.00006316512,0.0003685908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005635519,0.001534602,0.297029,0.0007515141,0.0009303973,0.0002532251,0.00006630077,5.673834e-7,0.04154783,0.000005521236,0.381075,0.2762424],"study_design_scores_gemma":[0.004529904,0.0001132626,0.01475155,0.0002950715,0.0005009369,0.00006650662,0.00007334188,0.00008306486,0.1044101,0.00002666534,0.8747867,0.0003628403],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9219273,0.006899258,0.00001147101,0.004685367,0.000435688,0.0001338378,0.00003691299,0.0000838384,0.06578634],"genre_scores_gemma":[0.9560122,0.004021267,0.0004161478,0.00143845,0.001743372,0.00002797893,0.00001891777,0.00003073674,0.03629095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4937117,"threshold_uncertainty_score":0.9896385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09455864515885498,"score_gpt":0.3784568846899853,"score_spread":0.2838982395311304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}