{"id":"W2148644613","doi":"10.1373/clinchem.2015.239863","title":"Validation of New Cancer Biomarkers: A Position Statement from the European Group on Tumor Markers","year":2015,"lang":"en","type":"review","venue":"Clinical Chemistry","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Science Foundation Ireland; Irish Cancer Society; Novartis; Fashion Footwear Association of New York; AstraZeneca; Breast Cancer Research Foundation","keywords":"Biomarker; Medicine; Cancer; Cancer biomarkers; Biomarker discovery; Oncology; Internal medicine; Proteomics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03303686,0.001628502,0.00229653,0.004762074,0.0009078537,0.003317396,0.003301782,0.008071442,0.001592553],"category_scores_gemma":[0.01702514,0.0008326141,0.002367253,0.003197149,0.003098713,0.004438575,0.003395405,0.00878443,0.002071125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003068285,"about_ca_system_score_gemma":0.01744193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002121377,"about_ca_topic_score_gemma":0.002013865,"domain_scores_codex":[0.9903928,0.002835015,0.001709945,0.0007474839,0.003673827,0.0006410535],"domain_scores_gemma":[0.9779463,0.009909037,0.002025323,0.0008018912,0.008344006,0.0009734945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002274117,0.0001791958,0.001262071,0.0138574,0.0002053491,0.0005510299,0.0002698879,0.0007643055,0.004312973,0.04259436,0.1709294,0.7648466],"study_design_scores_gemma":[0.0000443392,0.00009671622,0.0007945931,0.006158296,0.0001501766,0.0006153831,0.00007044721,0.0001565903,0.00226783,0.006085322,0.9835254,0.00003489429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.0005041337,0.9403771,0.004554481,0.04142461,0.007632124,0.0001767881,0.0002513466,0.00005796732,0.005021391],"genre_scores_gemma":[0.006002387,0.9526833,0.01184561,0.02030121,0.003776891,0.0004614242,0.0008549302,0.00004702417,0.004027253],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.03303686,"threshold_uncertainty_score":0.1747177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1698293150725706,"score_gpt":0.4462481256435051,"score_spread":0.2764188105709344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}