{"id":"W2148713472","doi":"10.1016/j.chembiol.2007.10.013","title":"Mechanism and Substrate Recognition of Human Holo ACP Synthase","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Institute of General Medical Sciences; Ontario Genomics Institute; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Transferase; Biochemistry; Bacillus subtilis; Biology; Acyl carrier protein; Stereochemistry; Mutagenesis; Enzyme; Binding site; Chemistry; Biosynthesis; Mutant; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756203,0.000216433,0.0001471082,0.00009394949,0.0001422195,0.0003450421,0.0001883871,0.0003105539,0.00106121],"category_scores_gemma":[0.0002450912,0.0001376091,0.0001319997,0.00006674052,0.0002299781,0.0002483655,0.0001826489,0.0002321767,0.000625041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003948947,"about_ca_system_score_gemma":0.0001861106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003769984,"about_ca_topic_score_gemma":0.0002404709,"domain_scores_codex":[0.9998827,0.00002217223,0.000006039519,0.00003970315,0.00002821178,0.00002103952],"domain_scores_gemma":[0.9998918,0.00003440663,0.00001788107,0.00001650634,0.00001383746,0.00002560265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002743207,0.00003786646,0.00154799,0.00008062139,0.000009677338,0.0005383405,0.0001002711,0.0005258278,0.9878685,0.002185254,0.0002390576,0.00659235],"study_design_scores_gemma":[0.00004861952,0.0001809638,0.005149024,0.000009532871,0.000009939113,0.001578058,0.00008081031,0.01080574,0.977022,0.0009050122,0.004196624,0.00001373573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896882,0.001595124,0.006472829,0.0002384417,0.00002538585,0.00002709767,0.00009882082,0.0001388422,0.001715311],"genre_scores_gemma":[0.9958152,0.0003708288,0.001859314,0.00004229401,0.000008557304,0.00001279621,0.0001871155,0.00001184836,0.001691999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106121,"threshold_uncertainty_score":0.003550053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223443634648076,"score_gpt":0.3022119762318223,"score_spread":0.2798676127670147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}