{"id":"W2148713472","doi":"10.1016/j.chembiol.2007.10.013","title":"Mechanism and Substrate Recognition of Human Holo ACP Synthase","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Institute of General Medical Sciences; Ontario Genomics Institute; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Transferase; Biochemistry; Bacillus subtilis; Biology; Acyl carrier protein; Stereochemistry; Mutagenesis; Enzyme; Binding site; Chemistry; Biosynthesis; Mutant; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003037067,0.0001485094,0.0001636994,0.00002226966,0.00005455702,0.000006537232,0.0001586505,0.0004010871,0.00007419158],"category_scores_gemma":[0.0001006324,0.00014126,0.00007000491,0.00006484553,0.0003156362,0.000001716939,0.0001452054,0.0001439073,0.000004326034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007411126,"about_ca_system_score_gemma":0.00002831857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001512347,"about_ca_topic_score_gemma":0.000004968765,"domain_scores_codex":[0.9989706,0.00002440538,0.0002324859,0.0003899524,0.00006558286,0.0003169625],"domain_scores_gemma":[0.999408,0.00001447942,0.00008341613,0.0002536183,0.0001042745,0.0001361797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008378589,0.00005935796,0.0003660573,0.00005140335,0.00003368189,0.000007032938,0.000006755864,1.796315e-8,0.9962406,0.0001037064,0.00007267515,0.002974977],"study_design_scores_gemma":[0.0004286611,0.0001824406,0.000310063,0.00001258089,0.00001036934,0.0000430886,0.0000384345,0.000001114935,0.9958444,0.001937596,0.001030542,0.0001607344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996119,0.0006131702,0.0005747671,0.00005257489,0.00002771798,0.00009020881,0.0000382234,0.00001155313,0.002472757],"genre_scores_gemma":[0.9985718,0.000175017,0.0002726515,0.00007413235,0.0001373963,0.000008345763,0.0005322679,0.0000151885,0.0002131581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002814242,"threshold_uncertainty_score":0.5760416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0223443634648076,"score_gpt":0.3022119762318223,"score_spread":0.2798676127670147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}