{"id":"W2148724942","doi":"10.1161/circresaha.109.215970","title":"Extracellular K <sup>+</sup> Is a Prerequisite for the Function and Plasma Membrane Stability of HERG Channels","year":2010,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"hERG; Chemistry; Ion channel; Patch clamp; Potassium channel; Biophysics; HEK 293 cells; Repolarization; Extracellular; Cardiac action potential; Long QT syndrome; Membrane potential; Cell biology; Electrophysiology; Biochemistry; Biology; Internal medicine; Receptor; QT interval; Medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607246,0.0002773437,0.0002351567,0.0001052307,0.0001603712,0.0005685659,0.0003008913,0.000468142,0.002200596],"category_scores_gemma":[0.0005926085,0.00009213216,0.0002316403,0.0001112605,0.0005433723,0.0004944871,0.0003410869,0.0003729832,0.0007230056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662638,"about_ca_system_score_gemma":0.000249608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495673,"about_ca_topic_score_gemma":0.0002031202,"domain_scores_codex":[0.9997348,0.0000329356,0.00004421597,0.00005353399,0.00008636418,0.00004808046],"domain_scores_gemma":[0.9995782,0.00009966215,0.0001759122,0.00003249478,0.00006730885,0.00004642249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005776111,0.00001893636,0.001628967,0.0001971268,0.000009266823,0.0003504745,0.0000179236,0.0001771312,0.992844,0.0004927147,0.0001290009,0.003556801],"study_design_scores_gemma":[0.00006296176,0.0005484615,0.0309029,0.00004201023,0.00004017734,0.002811079,0.0001145604,0.001481023,0.9565349,0.001180447,0.006258206,0.00002334601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776362,0.006528796,0.009790211,0.0007978483,0.0001046134,0.00006121485,0.0008895515,0.0002599973,0.003931587],"genre_scores_gemma":[0.9959467,0.0007400078,0.002242454,0.0001305325,0.00002097372,0.00003009203,0.0003043005,0.00002111241,0.000563704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200596,"threshold_uncertainty_score":0.00736177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05320887494542823,"score_gpt":0.3320666633411164,"score_spread":0.2788577883956882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}