{"id":"W2148735291","doi":"10.1210/en.2007-1443","title":"Distinct Modes of Activation of Phosphatidylinositol 3-Kinase in Response to Cyclic Adenosine 3′, 5′-Monophosphate or Insulin-Like Growth Factor I Play Different Roles in Regulation of Cyclin D1 and p27Kip1 in FRTL-5 Cells","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of North Carolina at Chapel Hill; University of Toronto; Meiji University; Interthyr Research Foundation","keywords":"Cyclin-dependent kinase; Kinase; Endocrinology; Biology; Phosphatidylinositol; Internal medicine; Cyclin D1; Protein kinase A; Cyclin-dependent kinase 4; Retinoblastoma protein; Cell biology; Cyclin-dependent kinase 2; Biochemistry; Cell cycle; Medicine; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008566098,0.0003702526,0.0002022547,0.0003752833,0.000136768,0.0003235139,0.0002086283,0.0002232679,0.0008598145],"category_scores_gemma":[0.00009267451,0.0001579698,0.0003820518,0.0001822289,0.0002342082,0.0001977964,0.0001665319,0.000541474,0.0002900383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006167802,"about_ca_system_score_gemma":0.0003176417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001809165,"about_ca_topic_score_gemma":0.002317203,"domain_scores_codex":[0.9998784,0.00001192946,0.00001062494,0.00002644496,0.00002911771,0.00004355889],"domain_scores_gemma":[0.9999267,0.00001734489,0.00001348882,0.000008366399,0.000009522933,0.00002459753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206115,0.000009535083,0.0002466211,0.00002536302,0.000002396119,0.00004352461,0.00001993221,0.00003112003,0.9987343,0.00009688264,0.0000162826,0.0006533657],"study_design_scores_gemma":[0.00002559523,0.0002104421,0.01978624,0.000007120611,0.00002037063,0.0002247506,0.00007983606,0.0007951185,0.9769024,0.000115783,0.001822385,0.000009954172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918354,0.003138531,0.001829112,0.0001260183,0.00002799831,0.0000255785,0.0005532033,0.00005537282,0.002408872],"genre_scores_gemma":[0.9954046,0.00106279,0.0009869543,0.00005349716,0.00001045403,0.00004114628,0.0005880497,0.00000779053,0.001844706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809165,"threshold_uncertainty_score":0.004475057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727770483737128,"score_gpt":0.2581121120423607,"score_spread":0.2408344072049894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}