{"id":"W2148735291","doi":"10.1210/en.2007-1443","title":"Distinct Modes of Activation of Phosphatidylinositol 3-Kinase in Response to Cyclic Adenosine 3′, 5′-Monophosphate or Insulin-Like Growth Factor I Play Different Roles in Regulation of Cyclin D1 and p27Kip1 in FRTL-5 Cells","year":2008,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of North Carolina at Chapel Hill; University of Toronto; Meiji University; Interthyr Research Foundation","keywords":"Cyclin-dependent kinase; Kinase; Endocrinology; Biology; Phosphatidylinositol; Internal medicine; Cyclin D1; Protein kinase A; Cyclin-dependent kinase 4; Retinoblastoma protein; Cell biology; Cyclin-dependent kinase 2; Biochemistry; Cell cycle; Medicine; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376814,0.0002396122,0.0008363865,0.0008365664,0.00001748121,0.0000019811,0.0001124226,0.0001751318,0.00003423123],"category_scores_gemma":[0.0005727954,0.0002151452,0.00006057886,0.0005594727,0.0001680716,0.00007605429,0.00009252215,0.000280485,0.000001709102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066142,"about_ca_system_score_gemma":0.0001273805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006956112,"about_ca_topic_score_gemma":0.0004854775,"domain_scores_codex":[0.997668,0.0002950031,0.001048651,0.0004079369,0.0002516646,0.0003287961],"domain_scores_gemma":[0.9986706,0.0004514711,0.0003651319,0.0003359398,0.00009432061,0.0000825231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01340379,0.0006090984,0.2286952,0.0001250509,0.00002596546,0.0001055225,0.002062238,0.000726671,0.7528237,0.00006834679,0.00001714404,0.001337297],"study_design_scores_gemma":[0.003511993,0.0004763257,0.5077034,0.0002230589,0.0000105129,0.00001531021,0.00007090874,0.0004060068,0.4874497,0.0000384147,0.00001103632,0.00008336292],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997826,0.0005775617,0.0002541088,0.0003177659,0.0000929991,0.0008363599,0.00005519045,0.00001509531,0.00002496555],"genre_scores_gemma":[0.9989133,0.0003837457,0.0004946797,0.00003739096,0.00001414956,0.00004825627,0.00003334151,0.00002835856,0.00004676143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2790082,"threshold_uncertainty_score":0.8773366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01727770483737128,"score_gpt":0.2581121120423607,"score_spread":0.2408344072049894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}