{"id":"W2148743957","doi":"10.1182/blood-2006-01-0092","title":"Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results","year":2006,"lang":"en","type":"review","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Fogarty International Center; European Commission","keywords":"Imatinib mesylate; Tyrosine kinase; Philadelphia chromosome; Fluorescence in situ hybridization; Imatinib; ABL; Myeloid leukemia; Cancer research; Medicine; breakpoint cluster region; Tyrosine-kinase inhibitor; Internal medicine; Oncology; Biology; Bioinformatics; Gene; Genetics; Cancer; Chromosomal translocation; Chromosome; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007879431,0.0006964508,0.00201441,0.0006126213,0.0005675764,0.00009080307,0.00006861505,0.0001999117,6.384407e-7],"category_scores_gemma":[0.0009810688,0.0005527577,0.0002453003,0.0004059995,0.00006236872,0.0001419425,0.00004653415,0.0001951124,2.012911e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000677965,"about_ca_system_score_gemma":0.0002934647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003513545,"about_ca_topic_score_gemma":0.00001937552,"domain_scores_codex":[0.9968474,0.0002624209,0.001114802,0.001066397,0.0001492821,0.0005596822],"domain_scores_gemma":[0.9958232,0.002720485,0.0005932058,0.0003546423,0.0002206759,0.0002877803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003283917,0.0004239695,0.00008576111,0.03606408,0.0004049363,0.000006674516,0.0005946162,1.955813e-7,0.0001345717,0.00001018101,0.00008868429,0.9618579],"study_design_scores_gemma":[0.03312887,0.003812048,0.00005091381,0.1654183,0.02512197,0.0001584257,0.0002005833,0.000006959165,0.001809721,0.00006515926,0.7693691,0.0008580156],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006484784,0.9765157,0.002977403,0.0002983974,0.0002436066,0.01174942,0.001662823,0.00006239017,0.000005520863],"genre_scores_gemma":[0.0002407219,0.7922041,0.19941,0.00002572305,0.0003863028,0.006220387,0.001316632,0.0001428876,0.00005322278],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9609999,"threshold_uncertainty_score":0.9996924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1864627210656154,"score_gpt":0.4071127916725872,"score_spread":0.2206500706069719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}