{"id":"W2148746613","doi":"10.1093/hmg/10.22.2469","title":"Selection of a mtDNA sequence variant in hepatocytes of heteroplasmic mice is not due to differences in respiratory chain function or efficiency of replication","year":2001,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Killam Trusts; Faculty of Medicine, McGill University; McGill University","keywords":"Biology; Genotype; Heteroplasmy; Mitochondrial DNA; Respiratory chain; Genetics; Molecular biology; Mitochondrion; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002738665,0.0002205361,0.0002498245,0.0004695535,0.0001705645,0.0002861011,0.0002664824,0.0002647361,0.001568666],"category_scores_gemma":[0.0003279499,0.0002524008,0.0001926223,0.0001100173,0.0002486162,0.0001658043,0.0002511597,0.0006022663,0.0005306843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315657,"about_ca_system_score_gemma":0.00008349508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002527353,"about_ca_topic_score_gemma":0.0005548738,"domain_scores_codex":[0.9996631,0.00005249593,0.00003635195,0.00009787947,0.0001063294,0.00004384154],"domain_scores_gemma":[0.9993218,0.00009579847,0.0002120939,0.0001177125,0.0000556747,0.000197049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010831,0.00001486453,0.0008907311,0.000005785458,0.000002760886,0.00003751532,0.00001349147,0.000007217464,0.998472,0.00004350468,0.000006095773,0.0003977471],"study_design_scores_gemma":[0.00004777498,0.0009004695,0.06551623,0.00001316175,0.00002214686,0.001852714,0.00007985024,0.0009237513,0.9293833,0.0001476123,0.001100192,0.00001284246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961286,0.0002133452,0.002767902,0.00003259643,0.00001254891,0.00001870692,0.0001539976,0.00003847301,0.0006337616],"genre_scores_gemma":[0.9929408,0.0001901843,0.003425426,0.0000504665,0.00001316668,0.00005324264,0.000489932,0.00006724046,0.002769576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568666,"threshold_uncertainty_score":0.005247712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04099580133433151,"score_gpt":0.2878555390383184,"score_spread":0.2468597377039869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}