{"id":"W2148749248","doi":"10.1038/ng.2897","title":"Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility","year":2014,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1079,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"FP7 Health; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Medical Research Council; Novo Nordisk Fonden; Instituto Mexicano del Seguro Social; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Commission; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute for Health and Care Research; National Institutes of Health; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Wellcome Trust; Consejo Nacional de Ciencia y Tecnología; British Heart Foundation","keywords":"Genome-wide association study; Biology; Genetic architecture; Genetics; Genetic association; Single-nucleotide polymorphism; Genetic genealogy; Allele; Type 2 diabetes; 1000 Genomes Project; Meta-analysis; Evolutionary biology; Quantitative trait locus; Gene; Genotype; Diabetes mellitus; Population; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003099081,0.001150948,0.002902403,0.001776039,0.0001735365,0.001111063,0.001261319,0.001180018,0.002044036],"category_scores_gemma":[0.004206784,0.0004378815,0.001832125,0.002834541,0.0004526251,0.0007334698,0.0009299035,0.001843271,0.0004847797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000545193,"about_ca_system_score_gemma":0.001636271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002581288,"about_ca_topic_score_gemma":0.006183269,"domain_scores_codex":[0.9992442,0.0002585245,0.00008839414,0.0002150026,0.0001529996,0.0000409877],"domain_scores_gemma":[0.9972903,0.002004561,0.000226469,0.0001156975,0.0002780525,0.00008500437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000597252,0.00004178123,0.01134446,0.01734657,0.0105648,0.0003665219,0.00006612469,0.000752358,0.001172204,0.003215303,0.01944419,0.9350885],"study_design_scores_gemma":[0.0006464441,0.0004958066,0.1017153,0.02531099,0.05722013,0.006386287,0.0003458368,0.001832973,0.002240183,0.04090414,0.7625918,0.0003101412],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0006067029,0.9971826,0.0007848809,0.0008047,0.0001515257,0.000003748001,0.0001721978,0.00001361869,0.0002799832],"genre_scores_gemma":[0.006701093,0.9902532,0.001306115,0.0007457641,0.000433236,0.00001079969,0.0002986677,0.000008467898,0.0002427047],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003099081,"threshold_uncertainty_score":0.01638973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326100269849037,"score_gpt":0.3171458462766457,"score_spread":0.284535819291742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}