{"id":"W2148754173","doi":"10.1128/jvi.76.15.7874-7882.2002","title":"Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Biology; Cyclin-dependent kinase; Herpes simplex virus; Viral replication; Virology; Lymphocytic choriomeningitis; Vaccinia; Virus; CDK inhibitor; Kinase; Cell biology; Cell cycle; Cell; Biochemistry; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009297573,0.0003059224,0.0001668705,0.0001350269,0.0001427529,0.0002291929,0.0001755737,0.0002066143,0.001373182],"category_scores_gemma":[0.0001119707,0.0001075325,0.0001802915,0.00008462121,0.0001614,0.0001858593,0.00009531925,0.0004574552,0.0003110948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002948618,"about_ca_system_score_gemma":0.0002666873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005293541,"about_ca_topic_score_gemma":0.001390531,"domain_scores_codex":[0.9999356,0.000008410585,0.000007265467,0.00001287952,0.00002343095,0.00001235417],"domain_scores_gemma":[0.9999526,0.00001515152,0.000008607769,0.000006335747,0.000009051041,0.000008254036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258174,0.00005586749,0.0005037008,0.0001281264,0.00001030544,0.00002698226,0.000009121953,0.00009157266,0.9896318,0.000422336,0.0001247177,0.008869749],"study_design_scores_gemma":[0.00004231023,0.0002722582,0.004866595,0.000007873732,0.00001435467,0.0001659553,0.00001854029,0.0006901438,0.9858773,0.0001191209,0.007922803,0.000002724525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9460842,0.02970141,0.007565948,0.0004911756,0.0002735959,0.000139087,0.0005575238,0.0002021102,0.01498489],"genre_scores_gemma":[0.9755841,0.01215706,0.006320699,0.0002613461,0.00006134357,0.00009575798,0.0006264365,0.00002102425,0.004872352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001373182,"threshold_uncertainty_score":0.00459373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277686679282679,"score_gpt":0.287551291112141,"score_spread":0.2647744243193142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}