{"id":"W2148754173","doi":"10.1128/jvi.76.15.7874-7882.2002","title":"Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute","keywords":"Biology; Cyclin-dependent kinase; Herpes simplex virus; Viral replication; Virology; Lymphocytic choriomeningitis; Vaccinia; Virus; CDK inhibitor; Kinase; Cell biology; Cell cycle; Cell; Biochemistry; In vitro; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006489605,0.0002039856,0.0005965137,0.0001978006,0.0001096787,0.00001009279,0.00009590978,0.0001433523,0.0001858483],"category_scores_gemma":[0.0001639112,0.0001558025,0.00007685663,0.0001821079,0.0002559015,0.00009596031,0.00007017483,0.0002757023,0.000003158847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006736499,"about_ca_system_score_gemma":0.0000563767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005665577,"about_ca_topic_score_gemma":0.00001101737,"domain_scores_codex":[0.9979951,0.0001504877,0.001006555,0.0002823198,0.0003219428,0.0002435616],"domain_scores_gemma":[0.9985572,0.00007476918,0.0008281436,0.0001703243,0.0002402604,0.0001293067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006719783,0.001194573,0.002117251,0.00005857396,0.0001806061,0.0001070273,0.0006212036,0.000004628584,0.9898432,0.00005194344,0.001240972,0.003907979],"study_design_scores_gemma":[0.003977982,0.002648022,0.005278807,0.00008477185,0.0004065716,0.0000799296,0.0002080865,0.00008213425,0.9822751,0.0001094829,0.004668349,0.0001808041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938321,0.004322368,0.00002218471,0.001238686,0.00007640118,0.0003702993,0.0000167975,0.00001046982,0.0001107233],"genre_scores_gemma":[0.9975739,0.001243339,0.0006390532,0.0001217348,0.00006602823,0.000004738977,0.00001403543,0.00001792668,0.0003192372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007568205,"threshold_uncertainty_score":0.6353443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277686679282679,"score_gpt":0.287551291112141,"score_spread":0.2647744243193142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}