{"id":"W2148760132","doi":"10.1093/nar/gkf398","title":"The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides","year":2002,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":315,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Zinc finger; Biology; DNA methylation; DNA; Consensus sequence; Binding site; Promoter; Cell biology; Transcription factor; Gene; Biochemistry; Peptide sequence; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0014317,0.0002896316,0.0002521647,0.0001469761,0.001137979,0.0004352365,0.0005356005,0.0003016446,0.0002106459],"category_scores_gemma":[0.0002430396,0.0002264848,0.0001133852,0.0003484394,0.0008036767,0.00001053643,0.0004813225,0.000535669,0.0001047006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008644834,"about_ca_system_score_gemma":0.00007076798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002937885,"about_ca_topic_score_gemma":0.00003327154,"domain_scores_codex":[0.9970739,0.0003473711,0.000352119,0.0007311014,0.0005425739,0.0009528955],"domain_scores_gemma":[0.9986344,0.0001544743,0.0001211005,0.0006623449,0.0002012431,0.0002264573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006923292,0.00004877982,0.001340667,0.00003161303,0.0001040626,0.00002404663,0.0003673339,0.000001846654,0.9780871,0.0002962409,0.005950939,0.01367819],"study_design_scores_gemma":[0.00284586,0.001320704,0.001636152,0.0002504336,0.00004290503,0.0002307302,0.004572415,0.01117699,0.7976704,0.002271289,0.1766095,0.001372584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938001,0.001146836,0.00001993912,0.001342669,0.00008521264,0.0006724006,0.00008087064,0.00003099039,0.002820978],"genre_scores_gemma":[0.9905378,0.002005594,0.001031259,0.00004284015,0.0001353762,0.0001114856,0.00003308313,0.0000766985,0.006025926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1804166,"threshold_uncertainty_score":0.9235781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08674780694806115,"score_gpt":0.320604747547083,"score_spread":0.2338569405990218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}