{"id":"W2148772010","doi":"10.1124/dmd.107.015396","title":"Effect of Arylamine Acetyltransferase Nat3 Gene Knockout on N-Acetylation in the Mouse","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Acetylation; Arylamine N-acetyltransferase; Acetyltransferase; N-acetyltransferase; Gene; Biology; Genetics; Acetyltransferases; Gene knockout; Knockout mouse; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104946,0.0001203965,0.0001321335,0.00007435398,0.00005235992,0.00001319932,0.00006854037,0.00008294126,0.000002334414],"category_scores_gemma":[0.00004833188,0.00008648438,0.00005357144,0.0001074178,0.00003897016,0.000006486001,0.00001310276,0.00006783918,0.000001166505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004237026,"about_ca_system_score_gemma":0.000006586505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003132499,"about_ca_topic_score_gemma":0.00003680472,"domain_scores_codex":[0.9991589,0.0001660316,0.0002033968,0.0001925456,0.0001434554,0.0001356693],"domain_scores_gemma":[0.9996292,0.00006042535,0.00005433618,0.000183788,0.00003765772,0.00003459171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004155476,0.00006423918,0.0008503178,0.00002408939,0.000008619008,0.000001157619,0.0002205058,0.0001128686,0.9833924,0.0003438779,0.00001634309,0.01455009],"study_design_scores_gemma":[0.0008990267,0.0002503668,0.03941039,0.000006816235,0.00002985077,0.000001395911,0.00003895664,0.00004077977,0.9584271,0.00005151084,0.0007526634,0.0000911624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942588,0.002601532,0.002311291,0.00007771788,0.00006820648,0.0002695439,0.00002276553,0.00000430818,0.0003858554],"genre_scores_gemma":[0.9985836,0.0006280058,0.000095861,0.0001047966,0.0001580528,0.00001177159,0.0003615229,0.0000104377,0.00004593782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03856007,"threshold_uncertainty_score":0.3526731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00364407124590312,"score_gpt":0.2473201583220118,"score_spread":0.2436760870761087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}