{"id":"W2148778216","doi":"10.1128/iai.71.3.1548-1550.2003","title":"The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity","year":2003,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Heart, Lung, and Blood Institute; U.S. Public Health Service","keywords":"Superantigen; Exotoxin; Biology; Microbiology; Major histocompatibility complex; Zinc; MHC class II; Immunology; Chemistry; Immune system; T cell; Toxin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037482,0.0001203968,0.0002981412,0.00005148737,0.0001648346,0.0002719914,0.000188311,0.0001596883,0.0007647062],"category_scores_gemma":[0.0002531489,0.0001005474,0.00009360467,0.0000860859,0.0002309473,0.0001303637,0.0001367213,0.0002925151,0.0002403097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232864,"about_ca_system_score_gemma":0.0004192069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009833955,"about_ca_topic_score_gemma":0.001228609,"domain_scores_codex":[0.9999049,0.00001468044,0.000005893025,0.00001664944,0.00003382571,0.00002411244],"domain_scores_gemma":[0.9999107,0.00001950877,0.00002118963,0.000007455274,0.00001310654,0.00002793088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004053564,0.00002896279,0.0006699793,0.00004883653,0.000005639056,0.000147134,0.00002147219,0.0008652636,0.9942797,0.0006979277,0.0001135959,0.002716044],"study_design_scores_gemma":[0.00007052184,0.0001872629,0.004582048,0.000006942999,0.00001137342,0.0004853702,0.00004507187,0.003433992,0.98873,0.0004146028,0.002022991,0.000009866118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951136,0.0002776767,0.002894719,0.00005376565,0.00001033118,0.00001214459,0.00006204224,0.0000365984,0.001539209],"genre_scores_gemma":[0.9981317,0.00008942338,0.001327661,0.00001752436,0.000001707537,0.000004299619,0.00006889134,0.000005392756,0.0003535123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009833955,"threshold_uncertainty_score":0.002558172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04614438697573595,"score_gpt":0.3222167511219559,"score_spread":0.2760723641462199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}