{"id":"W2148786649","doi":"10.1124/mol.112.080879","title":"CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity","year":2012,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Agonist; Allosteric regulation; Chemistry; Allosteric modulator; Receptor; Signal transduction; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004128131,0.0005388054,0.0006316728,0.0003399873,0.0003578734,0.0005240543,0.0005013035,0.000377574,0.006469424],"category_scores_gemma":[0.0003672906,0.0003246642,0.0003085186,0.0002128025,0.0003605268,0.0003612967,0.000383423,0.0008739466,0.001094756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003333814,"about_ca_system_score_gemma":0.000337006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000767991,"about_ca_topic_score_gemma":0.002005031,"domain_scores_codex":[0.999805,0.00004176616,0.00001540047,0.00002766098,0.00005327244,0.00005690293],"domain_scores_gemma":[0.9998651,0.00004706516,0.0000242887,0.00002589363,0.00002061072,0.0000169871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000806167,0.0001020767,0.0002521714,0.000203836,0.0000318078,0.0001168549,0.00004668707,0.0001937764,0.9764791,0.003332346,0.0005398907,0.01789526],"study_design_scores_gemma":[0.0002015439,0.001148468,0.005652984,0.00004751523,0.0001428036,0.00207579,0.00007587439,0.001147825,0.9708132,0.001192273,0.01746677,0.00003497871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156018,0.01833973,0.01375467,0.001512442,0.0002938482,0.0003415166,0.0009781345,0.0008504897,0.04832736],"genre_scores_gemma":[0.9769793,0.006531631,0.004769592,0.0008531784,0.00008308826,0.0001179749,0.0005696982,0.00006163587,0.01003396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006469424,"threshold_uncertainty_score":0.02164239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653604471026877,"score_gpt":0.3045057877786254,"score_spread":0.2879697430683566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}