{"id":"W2148793188","doi":"10.4049/jimmunol.0901528","title":"Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 <i>Trans</i> Signaling in the Local Maintenance of Th17 Cells","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Cell biology; CD28; Biology; T cell; Effector; IL-2 receptor; Signal transduction; ZAP70; Cytokine; Population; Immunology; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000987591,0.0001552225,0.0003884683,0.0001346515,0.000115859,0.000004005493,0.0005178002,0.0002496173,0.00003556345],"category_scores_gemma":[0.00004663811,0.00008534741,0.0001732451,0.0001149176,0.0003477696,0.00009559312,0.00003865188,0.0004059054,0.000003628888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001759004,"about_ca_system_score_gemma":0.00006638181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003336698,"about_ca_topic_score_gemma":0.00004442332,"domain_scores_codex":[0.9984847,0.0004187337,0.0006905689,0.00009583835,0.00005302831,0.0002570949],"domain_scores_gemma":[0.9981006,0.0007007283,0.0007633113,0.0002481316,0.0001787191,0.000008499482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002099516,0.0001424116,0.0003320594,0.00004174267,0.0001274768,0.00000393121,0.003187792,0.0003377038,0.9906639,0.00008542958,0.00002527384,0.002952788],"study_design_scores_gemma":[0.002973814,0.0004020635,0.002391761,0.00009889913,0.0001352351,0.0001808969,0.002614037,0.000007519043,0.9897782,0.0006821116,0.0006550216,0.00008041922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946943,0.002456672,0.001678218,0.0002792854,0.0005722569,0.0002380474,0.00002936563,0.000004684337,0.00004718433],"genre_scores_gemma":[0.999036,0.000552943,0.0002288495,0.00001652035,0.00006117942,0.000008401609,0.000006992528,0.00001230622,0.00007684777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004341673,"threshold_uncertainty_score":0.3480366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008012781372952955,"score_gpt":0.2116999375479008,"score_spread":0.2036871561749478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}