{"id":"W2148795098","doi":"10.1161/hy0202.103481","title":"Fibrosis, Matrix Metalloproteinases, and Inflammation in the Heart of DOCA-Salt Hypertensive Rats: Role of ET <sub>A</sub> Receptors","year":2002,"lang":"en","type":"article","venue":"Hypertension","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; Canadian Institutes of Health Research; Montreal Clinical Research Institute","funders":"Hypertension Canada","keywords":"Fibronectin; Matrix metalloproteinase; Endocrinology; Extracellular matrix; Internal medicine; Cardiac fibrosis; Fibrosis; Cell adhesion molecule; Inflammation; Proinflammatory cytokine; Endothelin 1; Endothelin receptor; Receptor; Medicine; Receptor antagonist; Chemistry; Antagonist; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002542037,0.0001307948,0.0002263015,0.00006150386,0.0000379374,0.000008980286,0.00008575442,0.0001403419,0.000005178861],"category_scores_gemma":[0.0001295974,0.00009585894,0.0000704726,0.0001156348,0.00005672868,0.00001350963,0.00006355718,0.00008516441,0.000004061156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004698133,"about_ca_system_score_gemma":0.00001598716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005347333,"about_ca_topic_score_gemma":0.00001731586,"domain_scores_codex":[0.9990435,0.0001530458,0.0002712432,0.0002220399,0.0001689132,0.0001412477],"domain_scores_gemma":[0.9994236,0.00002358722,0.0001155282,0.0002744057,0.0001294311,0.00003346795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006123639,0.00005518248,0.0000606515,0.00002536904,0.0000125682,0.000001901422,0.0000861051,0.000007534708,0.9967346,0.0001218542,0.001134803,0.001698224],"study_design_scores_gemma":[0.0003725911,0.0004522559,0.0002338917,0.0000666669,0.00002434329,0.00004639994,0.0002060658,0.0002805712,0.9943386,0.0002092773,0.003661789,0.0001075932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938795,0.005242026,0.00002675442,0.0003553083,0.00004924987,0.0003555271,0.000008166224,0.000005675205,0.00007779087],"genre_scores_gemma":[0.997894,0.001125606,0.0004983754,0.000328036,0.00006093918,0.00002509675,0.00004449655,0.00001411279,0.000009326355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00411642,"threshold_uncertainty_score":0.3909014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009999623053575263,"score_gpt":0.2088019278949448,"score_spread":0.1988023048413695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}