{"id":"W2148800654","doi":"10.1210/en.2010-0521","title":"Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Kisspeptin; Neuropeptide Y receptor; Internal medicine; Endocrinology; Biology; Protein kinase A; MAPK/ERK pathway; Receptor; Signal transduction; Kinase; Hypothalamus; Neuropeptide; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007415,0.0002710143,0.0002830772,0.0001784463,0.0002346203,0.0001760238,0.0001202255,0.0001468102,0.001035853],"category_scores_gemma":[0.00008244297,0.0001697175,0.0003932722,0.000124371,0.0001645058,0.0002547967,0.0002408088,0.0003908171,0.0001966585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981056,"about_ca_system_score_gemma":0.0002178068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005930872,"about_ca_topic_score_gemma":0.0008791839,"domain_scores_codex":[0.9998857,0.00001079215,0.00001050926,0.00002589584,0.00003062587,0.00003647987],"domain_scores_gemma":[0.999965,0.000004606945,0.00001048133,0.000003753129,0.000004734464,0.00001148119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002611209,0.00002803689,0.0003785212,0.00006393882,0.000006371345,0.0001005968,0.00003170255,0.00004168386,0.9979531,0.00005898966,0.00002959637,0.001046251],"study_design_scores_gemma":[0.00008068894,0.0004339595,0.05901193,0.00001553186,0.00004311129,0.0006680797,0.0001828017,0.001888898,0.93397,0.0002482736,0.003444142,0.0000126714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961938,0.001455012,0.001031866,0.00007017136,0.00002116735,0.00002004839,0.0002842954,0.00001636996,0.000907269],"genre_scores_gemma":[0.9928212,0.00180998,0.00217381,0.00005004058,0.00001575998,0.00008397852,0.0004775805,0.000009474716,0.002558322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035853,"threshold_uncertainty_score":0.003465235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013987634534829,"score_gpt":0.2263073064643716,"score_spread":0.2123196719295427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}