{"id":"W2148800654","doi":"10.1210/en.2010-0521","title":"Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Kisspeptin; Neuropeptide Y receptor; Internal medicine; Endocrinology; Biology; Protein kinase A; MAPK/ERK pathway; Receptor; Signal transduction; Kinase; Hypothalamus; Neuropeptide; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004067401,0.0003538318,0.0005492984,0.0002688814,0.0001907933,0.00004217407,0.000157817,0.0001375489,0.00006859764],"category_scores_gemma":[0.002373708,0.0002768982,0.00007183269,0.0002292186,0.0004902381,0.000130373,0.0001740776,0.0009524568,0.0000135553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003245344,"about_ca_system_score_gemma":0.00005834522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002919156,"about_ca_topic_score_gemma":0.0001154903,"domain_scores_codex":[0.9974544,0.0004144131,0.0004479435,0.0008487124,0.0001908538,0.0006436721],"domain_scores_gemma":[0.9982532,0.0007238605,0.000199418,0.0006010974,0.00009709403,0.0001253772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002308965,0.00005601545,0.01046958,0.0000440977,0.00004664138,0.0002910596,0.0004003531,0.000003932445,0.9448259,0.0001744475,0.000006378777,0.04345069],"study_design_scores_gemma":[0.001189813,0.0002156724,0.1916078,0.00008192997,0.00008997302,0.001368509,0.0001912658,0.0004821318,0.8030059,0.0003570736,0.001154301,0.0002556529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935481,0.001039563,0.00002451542,0.003539819,0.0002086574,0.001134393,0.000006206109,0.0001592911,0.0003394371],"genre_scores_gemma":[0.9984588,0.00009473,0.0006379365,0.0001176431,0.0002521418,0.0001671631,0.000006813407,0.00006969423,0.0001951012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1811382,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013987634534829,"score_gpt":0.2263073064643716,"score_spread":0.2123196719295427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}