{"id":"W2148812452","doi":"10.1038/mt.2008.70","title":"Translation of Targeted Oncolytic Virotherapeutics from the Lab into the Clinic, and Back Again: A High-Value Iterative Loop","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jennerex Biotherapeutics (Canada)","funders":"","keywords":"Medicine; Sorafenib; Oncolytic virus; Drug development; Cancer; Oncology; Drug; Pharmacology; Cancer research; Internal medicine; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004204341,0.0002373115,0.0002316712,0.00003136635,0.0002051151,0.00002881935,0.0004083762,0.000174637,0.0001314765],"category_scores_gemma":[0.00002137771,0.00015005,0.0001451313,0.0001887264,0.0004759768,0.000006466748,0.00004800894,0.0002105902,0.00002947905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001522627,"about_ca_system_score_gemma":0.0001382439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001030928,"about_ca_topic_score_gemma":0.00008626962,"domain_scores_codex":[0.9980278,0.0007067422,0.0003176137,0.0003898667,0.0003111108,0.0002468566],"domain_scores_gemma":[0.9988742,0.000129267,0.0001213337,0.0006980014,0.0001165009,0.00006069978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001786077,0.0000931113,0.0004585707,0.00000363754,0.0003457902,0.000005587613,0.001756306,0.0001313854,0.9782254,0.00002087176,0.0001799904,0.01699332],"study_design_scores_gemma":[0.002521225,0.002279894,0.002084856,0.00001354658,0.0000216976,0.000005365361,0.0001060684,0.0004697322,0.9783864,0.0005562686,0.01333094,0.0002240185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773977,0.01727368,0.002425126,0.00198397,0.00005527781,0.0007002291,0.00003199136,0.000009198292,0.0001228383],"genre_scores_gemma":[0.9856735,0.009002591,0.0008991589,0.003730185,0.0001217287,0.00005014141,0.000119629,0.00005742862,0.0003456113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0167693,"threshold_uncertainty_score":0.6118863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03128702747015578,"score_gpt":0.3078615856946977,"score_spread":0.276574558224542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}