{"id":"W2148812452","doi":"10.1038/mt.2008.70","title":"Translation of Targeted Oncolytic Virotherapeutics from the Lab into the Clinic, and Back Again: A High-Value Iterative Loop","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jennerex Biotherapeutics (Canada)","funders":"","keywords":"Medicine; Sorafenib; Oncolytic virus; Drug development; Cancer; Oncology; Drug; Pharmacology; Cancer research; Internal medicine; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03454625,0.001086948,0.001573868,0.001926978,0.001646242,0.01043971,0.002553086,0.005605375,0.006025752],"category_scores_gemma":[0.02655748,0.0006400845,0.001443106,0.0009969634,0.007901343,0.01271413,0.008597926,0.01244199,0.003286188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005731573,"about_ca_system_score_gemma":0.01356452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332417,"about_ca_topic_score_gemma":0.001359282,"domain_scores_codex":[0.9836994,0.007553024,0.0009305651,0.0009328411,0.00608447,0.0007997651],"domain_scores_gemma":[0.9677029,0.02253259,0.001048359,0.002236105,0.004909444,0.001570538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000638399,0.0004867026,0.0007049814,0.0050486,0.0002118648,0.001344206,0.003836785,0.003974908,0.01592675,0.2592266,0.09204373,0.6165565],"study_design_scores_gemma":[0.0002216169,0.001501938,0.0007077966,0.003057232,0.0000982555,0.001212882,0.002477069,0.003640543,0.01110089,0.3572402,0.6185278,0.0002137263],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.01345839,0.1528887,0.2102045,0.5656957,0.02535412,0.001096837,0.0002368265,0.001206643,0.02985829],"genre_scores_gemma":[0.2002209,0.2865323,0.2741796,0.1815797,0.02732124,0.001548219,0.000537791,0.001356669,0.0267237],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.03454625,"threshold_uncertainty_score":0.1827003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03128702747015578,"score_gpt":0.3078615856946977,"score_spread":0.276574558224542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}