{"id":"W2148816655","doi":"10.1007/s11689-011-9072-9","title":"Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism","year":2011,"lang":"en","type":"article","venue":"Journal of Neurodevelopmental Disorders","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Ontario Ministry of Research and Innovation; Medical Research Council; Canadian Institutes of Health Research; Fondation de France; Hospital for Sick Children; Ministero della Salute; National Institute of Mental Health; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Autism Speaks; Sick Kids Foundation; Ontario Genomics Institute; Fondation Orange; National Institutes of Health; Ontario Genomics; Fondation FondaMental; Koninklijke Nederlandse Akademie van Wetenschappen; Hussman Foundation; Genome Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Health Research Board; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ontario Innovation Trust; University of Toronto","keywords":"Genetic architecture; Genetics; Autism; Genetic linkage; Heritability of autism; Linkage (software); Biology; Genetic association; Genome; Genome-wide association study; Gene; Computational biology; Single-nucleotide polymorphism; Genotype; Psychology; Quantitative trait locus; Phenotype; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007920732,0.001165383,0.001572998,0.006518542,0.001273627,0.002267894,0.001932417,0.001260343,0.004996954],"category_scores_gemma":[0.01748934,0.0008700855,0.002637478,0.004602821,0.001006247,0.001067944,0.003187501,0.001921588,0.002270036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004263566,"about_ca_system_score_gemma":0.002277853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001748683,"about_ca_topic_score_gemma":0.00388774,"domain_scores_codex":[0.9916387,0.002867826,0.0004975354,0.002649854,0.002000065,0.0003460752],"domain_scores_gemma":[0.9932373,0.003677384,0.0004806498,0.001368153,0.0009525811,0.0002839736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001321564,0.000633341,0.1189416,0.0005948661,0.004257888,0.002051722,0.0007082789,0.0119477,0.07887147,0.01994198,0.02039706,0.7403325],"study_design_scores_gemma":[0.001056566,0.0007875595,0.1251826,0.0000854481,0.002031677,0.008220309,0.0004047463,0.7170259,0.03424589,0.05809518,0.05240284,0.0004613505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.02258625,0.0002011997,0.97034,0.0002659174,0.00009303533,0.0001839524,0.001070974,0.004112808,0.001145714],"genre_scores_gemma":[0.1518367,0.0001276482,0.8400871,0.0002518501,0.000190509,0.0007872541,0.003482351,0.001002244,0.002234365],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007920732,"threshold_uncertainty_score":0.04188931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148402775273393,"score_gpt":0.3140473363816354,"score_spread":0.2725633086289015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}