{"id":"W2148824220","doi":"10.1186/1742-4690-8-48","title":"A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells","year":2011,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; amfAR, The Foundation for AIDS Research","keywords":"CD40; Dendritic cell; Cell biology; Immune system; Chemistry; Antibody; Gp41; Biology; Virology; Molecular biology; Cytotoxic T cell; Epitope; In vitro; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009067261,0.0002621423,0.0001476671,0.0001190088,0.0001141229,0.0002613527,0.0001627463,0.0003124242,0.001357473],"category_scores_gemma":[0.00007723982,0.00008020784,0.000194411,0.0001206035,0.0001190383,0.0001309906,0.0001646851,0.0003961195,0.0005003418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003631216,"about_ca_system_score_gemma":0.0001788776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002143596,"about_ca_topic_score_gemma":0.0002121468,"domain_scores_codex":[0.9999158,0.000008866195,0.00000488251,0.00002157525,0.00002188607,0.00002692774],"domain_scores_gemma":[0.9999474,0.00001121839,0.00001225492,0.000007209163,0.000006242724,0.0000156197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004969382,0.00001658641,0.00007139271,0.000020304,0.000001660989,0.0000262408,0.00000792376,0.00008615037,0.9991086,0.00005943302,0.00003199341,0.000519965],"study_design_scores_gemma":[0.00002550489,0.0001738821,0.0007360058,0.000003940269,0.000008927423,0.0001275666,0.00001106942,0.00113798,0.9957595,0.00003593674,0.00197738,0.000002234068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943728,0.0005250864,0.003052396,0.00008469333,0.00002755286,0.00004086224,0.0002067567,0.0001027122,0.001587263],"genre_scores_gemma":[0.9952374,0.0002772415,0.002382351,0.00005373461,0.0000104239,0.00002228135,0.0003614028,0.00001705695,0.001638165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357473,"threshold_uncertainty_score":0.004541159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01954830779488504,"score_gpt":0.2371565455162316,"score_spread":0.2176082377213466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}