{"id":"W2148824237","doi":"10.4049/jimmunol.1202749","title":"Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Medical Research Council; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"DNA; Biology; Cytoplasm; Endosome; Cell biology; Innate immune system; Herpes simplex virus; Virology; Intracellular; Virus; Molecular biology; Immune system; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003179196,0.0001019857,0.0002488771,0.0001015619,0.0000898183,0.00000844607,0.00009388269,0.00007519784,0.0001621868],"category_scores_gemma":[0.00028629,0.00005376562,0.0000818354,0.0001500929,0.00008354436,0.00009328959,0.00001841243,0.0001492193,0.00003249386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007388337,"about_ca_system_score_gemma":0.0000583591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009518128,"about_ca_topic_score_gemma":0.0001128691,"domain_scores_codex":[0.9990277,0.0002129529,0.0004184692,0.00006809746,0.0001034555,0.0001693458],"domain_scores_gemma":[0.999034,0.000250886,0.0002820119,0.0001597906,0.0002397375,0.0000335842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00178005,0.0007927541,0.0006824873,0.00003580057,0.0006209221,0.00001081334,0.0008388876,0.00003509428,0.3946701,0.00001706115,0.004341337,0.5961747],"study_design_scores_gemma":[0.005193551,0.004083366,0.03679804,0.0002532925,0.0004120657,0.000816014,0.001744253,0.00008510717,0.9211942,0.0007498213,0.02851169,0.0001586154],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951915,0.0006434091,0.0001815343,0.002867849,0.0001109153,0.000907958,0.00002834023,0.0000063668,0.00006216218],"genre_scores_gemma":[0.9986566,0.0004081059,0.0003660587,0.0001735586,0.00006248729,0.00006213977,0.000009517395,0.00001392646,0.0002475791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.596016,"threshold_uncertainty_score":0.2192498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956359071501363,"score_gpt":0.2745373356321333,"score_spread":0.2549737449171197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}