{"id":"W2148824237","doi":"10.4049/jimmunol.1202749","title":"Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; H. Lundbeck A/S; Lundbeckfonden; Medical Research Council; Novo Nordisk; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"DNA; Biology; Cytoplasm; Endosome; Cell biology; Innate immune system; Herpes simplex virus; Virology; Intracellular; Virus; Molecular biology; Immune system; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046575,0.0002475343,0.0002009179,0.0001614337,0.0001681447,0.000288008,0.0001001861,0.0001871964,0.001307347],"category_scores_gemma":[0.00009932363,0.0001147284,0.0002515055,0.0000829835,0.0002271284,0.0002398954,0.0002412912,0.0004349732,0.0004881837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053795,"about_ca_system_score_gemma":0.0003143109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889241,"about_ca_topic_score_gemma":0.0003697406,"domain_scores_codex":[0.9998581,0.0000232598,0.00001019181,0.00003089017,0.00003685797,0.00004064043],"domain_scores_gemma":[0.9999419,0.000006526119,0.00001379704,0.00001017586,0.00001421466,0.00001338572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729894,0.00001041312,0.0003786966,0.00004048907,0.000004704918,0.00006598089,0.00002137582,0.00001675711,0.9980096,0.0001085047,0.00003703063,0.001133373],"study_design_scores_gemma":[0.00001810285,0.0001537084,0.003734077,0.000007354342,0.000005727518,0.0004239138,0.00005179119,0.0003131527,0.9935098,0.0001226766,0.001656793,0.000002860771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893273,0.004238583,0.004288941,0.000215103,0.00006402127,0.00002487205,0.0002384291,0.0000511578,0.001551572],"genre_scores_gemma":[0.994754,0.0008585301,0.00152818,0.00004303385,0.000009773306,0.00001918827,0.0001938106,0.0000113946,0.002582174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307347,"threshold_uncertainty_score":0.004373491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956359071501363,"score_gpt":0.2745373356321333,"score_spread":0.2549737449171197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}